Comparison of normal and asthmatic subjects' responses to sulfate pollutant aerosols
Epidemiological studies support an association between elevated levels of sulfates and acute respiratory disease. To determine if these pollutants produce airway hyperreactivity, 16 normal and 17 asthmatic subjects inhaled a control NaCl aerosol and the following sulfates: ammonium sulfate, sodium bisulfate, ammonium bisulfate, and sulfuric acid. A Lovelace generator produced particles with an average MMAD of approx. 1.0 ..mu..m (sigma/sub g/ approx. = 2.0) and concentrations of 0.1 and 1.0 mg/m/sup 3/. By double-blind randomization, all subjects breathed these aerosols for a 16-minute period. To determine if sulfate inhalation caused increased reactivity to a known bronchoconstrictor, all subjects inhaled carbachol following each 16-minute exposure. Before, during, and after exposure, pulmonary function studies were performed. When compared to NaCl, sulfate (1 mg/m/sup 3/) produced significant reductions in airway conductance and flow rates in asthmatics. The two most sensitive asthmatics demonstrated changes even at 0.1 mg/m/sup 3/ sulfate. To a far more significant degree, the bronchoconstrictor action of carbachol was potentiated by sulfates more or less in relation to their acidity in normals and asthmatics.
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 7096979
- Report Number(s):
- UR-3490-1886; CONF-8009111-1
- Resource Relation:
- Conference: 5. international symposium on inhaled particles, Cardiff, UK, 8 Sep 1980
- Country of Publication:
- United States
- Language:
- English
Similar Records
Airway reactivity to nitrates in normal and mild asthmatic subjects
Airway responses to sulfate and sulfuric acid aerosols in asthmatics. An exposure-response relationship
Related Subjects
54 ENVIRONMENTAL SCIENCES
RESPIRATORY SYSTEM
SENSITIVITY
SULFATES
BIOLOGICAL EFFECTS
ACID SULFATES
AEROSOLS
AMMONIUM COMPOUNDS
ASTHMA
COMPARATIVE EVALUATIONS
CORRELATIONS
EPIDEMIOLOGY
INHALATION
MAN
SODIUM CHLORIDES
SULFURIC ACID
ALKALI METAL COMPOUNDS
ANIMALS
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISEASES
DISPERSIONS
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
INTAKE
MAMMALS
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM DISEASES
SODIUM COMPOUNDS
SOLS
SULFUR COMPOUNDS
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)