Causes of failing the draft ANSI Standard N13. 30 radiobioassay performance criterion for minimum detectable amount
The test methods used for PNL bioassay performance tests were evaluated by comparing the MDA based on performance tests results with MDA calculated by PNL using the bioassay laboratory's own quality control (QC) data. Two in vitro laboratories and two in vivo laboratories were studied and a correlation between the performance test MDA estimates and QC data was demonstrated. However, it was often necessary to examine the QC data to identify important characteristics of the blank distribution that affect the MDA calculation. Since the MDA equation must be based on the specific analysis and calculational methods of the procedure evaluated. Even when the correct MDA equation is applied, the MDA calculated will have a relatively large confidence interval when only a few replicates are used to estimate the standard deviation. For this reason, a relatively precise estimate of the MDA is generally only available when Poisson statistics may be applied. It was concluded that performance testing alone cannot provide all the information necessary to make an accurate estimate of the measurement process MDA. Review of the laboratory's QC data and the entire measurement procedure will be necessary. Specific recommendations for changes to draft ANSI N13.30 Performance Criteria for Radiobioassay'' are given. 10 refs., 18 figs., 11 tabs.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USNRC
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 7018467
- Report Number(s):
- NUREG/CR-5516; PNL-7217; ON: TI90007410; TRN: 90-006983
- Country of Publication:
- United States
- Language:
- English
Similar Records
Technical evaluation of draft ANSI Standard N13. 30, ''performance criteria for radiobioassay''
Application of the generic ANSI N13. 30 minimum detectable activity equation to multichannel analysis
Related Subjects
61 RADIATION PROTECTION AND DOSIMETRY
22 GENERAL STUDIES OF NUCLEAR REACTORS
21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS
29 ENERGY PLANNING
POLICY AND ECONOMY
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
RADIATION DETECTION
BIOASSAY
RADIOASSAY
PERFORMANCE TESTING
STATISTICAL MODELS
POISSON EQUATION
CESIUM 144
COMPARATIVE EVALUATIONS
DATA PROCESSING
EXPERIMENTAL DATA
IN VIVO
MANGANESE 54
MEASURING METHODS
OCCUPATIONAL SAFETY
PLUTONIUM 238
PROBABILISTIC ESTIMATION
QUALITY CONTROL
RADIATION PROTECTION
RADIONUCLIDE MIGRATION
REACTOR SAFETY
RECOMMENDATIONS
SAMPLING
STANDARDS
VARIATIONS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALI METAL ISOTOPES
ALPHA DECAY RADIOISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CESIUM ISOTOPES
CONTROL
DATA
DAYS LIVING RADIOISOTOPES
DETECTION
DIFFERENTIAL EQUATIONS
ELECTRON CAPTURE RADIOISOTOPES
ENVIRONMENTAL TRANSPORT
EQUATIONS
EVEN-EVEN NUCLEI
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
MANGANESE ISOTOPES
MASS TRANSFER
MATHEMATICAL MODELS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PARTIAL DIFFERENTIAL EQUATIONS
PLUTONIUM ISOTOPES
PROCESSING
RADIOISOTOPES
SAFETY
SECONDS LIVING RADIOISOTOPES
SILICON 32 DECAY RADIOISOTOPES
TESTING
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man
655003 - Medical Physics- Dosimetry
220900 - Nuclear Reactor Technology- Reactor Safety
210700 - Nuclear Power Plants- Regulation & Licensing
290300 - Energy Planning & Policy- Environment
Health
& Safety
293000 - Energy Planning & Policy- Policy
Legislation
& Regulation
054000 - Nuclear Fuels- Health & Safety
056000 - Nuclear Fuels- Legislation & Regulations- (1987-)
990200 - Mathematics & Computers