Biologic data, models, and dosimetric methods for internal emitters
The absorbed radiation dose from internal emitters has been and will remain a pivotal factor in assessing risk and therapeutic utility in selecting radiopharmaceuticals for diagnosis and treatment. Although direct measurements of absorbed dose and dose distributions in vivo have been and will continue to be made in limited situations, the measurement of the biodistribution and clearance of radiopharmaceuticals in human subjects and the use of this data is likely to remain the primary means to approach the calculation and estimation of absorbed dose from internal emitters over the next decade. Since several approximations are used in these schema to calculate dose, attention must be given to inspecting and improving the application of this dosimetric method as better techniques are developed to assay body activity and as more experience is gained in applying these schema to calculating absorbed dose. Discussion of the need for considering small scale dosimetry to calculate absorbed dose at the cellular level will be presented in this paper. Other topics include dose estimates for internal emitters, biologic data mathematical models and dosimetric methods employed. 44 refs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 7006021
- Report Number(s):
- BNL-43563; CONF-9005200-1; ON: DE90011224; TRN: 90-017649
- Resource Relation:
- Conference: Quantitative SPECT And dosimetry conference, Lund (Sweden), 5-12 May 1990
- Country of Publication:
- United States
- Language:
- English
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