Desferal (DFO) induced Ga-67 washout from normal tissue, tumor and abscess in experimental animals
In the experimental animal, desferal (DFO) given intravenously washes out Ga-67 from all tissues. This effect is not uniform: blood activity is reduced very markedly, while liver activity is less affected. Maximal effect of DFO occurs if given close to the Ga-67 injection. When the time interval between the two is increased, the absolute amount of Ga-67 excreted in the urine in excess of the spontaneous excretion is reduced. Administration of DFO does not effect Ga-67 gastrointestinal excretion. In three animal tumor models (EMT-6 sarcoma in Balb/c mice, spontaneous adenocarcinoma in mice, and spontaneous adenocarcinoma in the rabbit) and in sterile abscess-bearing rats, the administration of DFO 24 hrs after Ga-67-citrate improves significantly the target-to-nontarget ratio. Animals given 50 mg/kg DFO I.V. after Ga-67 citrate showed a significant reduction in the whole-body activity as seen in a one-week follow up.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); State Univ. of New York, Stony Brook (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6880111
- Report Number(s):
- BNL-28487; CONF-801082-3; TRN: 81-000489
- Resource Relation:
- Conference: ORAU radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 6 Oct 1980
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
RADIONUCLIDE KINETICS
ANIMAL TISSUES
DEFEROXAMINE
BIOLOGICAL EFFECTS
GALLIUM 67
EXCRETION
RADIOPHARMACEUTICALS
WASHOUT
TUMOR CELLS
BIOLOGICAL MODELS
CARCINOMAS
CITRATES
INTRAVENOUS INJECTION
MICE
RABBITS
SARCOMAS
URINE
AMINES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INFLAMMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRECIPITATION SCAVENGING
RADIOACTIVE MATERIALS
RADIOISOTOPES
RODENTS
SEPARATION PROCESSES
TISSUES
VERTEBRATES
WASTES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics