Radiobiological modeling with MarCell software
- Oak Ridge National Lab., TN (United States). Health Sciences Research Div.
A nonlinear system of differential equations that models the bone marrow cellular kinetics associated with radiation injury, molecular repair, and compensatory cell proliferation has been extensively documented. Recently, that model has been implemented as MarCell, a user-friendly MS-DOS computer program that allows users with little knowledge of the original model to evaluate complex radiation exposure scenarios. The software allows modeling with the following radiations: tritium beta, 100 kVp X, 250 kVp X, 22 MV X, {sup 60}Co, {sup 137}Cs, 2 MeV electrons, triga neutrons, D-T neutrons, and 3 blends of mixed-field fission radiations. The possible cell lineages are stem, stroma, and leukemia/lymphoma, and the available species include mouse, rat, dog, sheep, swine, burro, and man. An attractive mathematical feature is that any protracted protocol can be expressed as an equivalent prompt dose for either the source used or for a reference, such as 250 kVp X rays or {sup 60}Co. Output from MarCell includes: risk of 30-day mortality; risk of cancer and leukemia based either on cytopenia or compensatory cell proliferation; cell survival plots as a function of time or dose; and 4-week recovery kinetics following treatment. In this article, the program`s applicability and ease of use are demonstrated by evaluating a medical total body irradiation protocol and a nuclear fallout scenario.
- Research Organization:
- Oak Ridge Associated Universities, TN (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States); Defense Nuclear Agency, Washington, DC (United States); Department of the Army, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 684490
- Report Number(s):
- ORISE-99-0164-Vol.1; CONF-960536-PROC.-Vol.1; ON: DE99002903; TRN: IM9943%%181
- Resource Relation:
- Conference: 6. international radiopharmaceutical dosimetry symposium, Gatlinburg, TN (United States), 7-10 May 1996; Other Information: PBD: Jan 1999; Related Information: Is Part Of Sixth international radiopharmaceutical dosimetry symposium: Proceedings. Volume 1; S.-Stelson, A.T. [ed.] [comp.]; Stabin, M.G.; Sparks, R.B. [eds.]; Smith, F.B. [comp.]; PB: 386 p.
- Country of Publication:
- United States
- Language:
- English
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