Treatment planning for internal emitter therapy: Methods, applications and clinical implications
Abstract
Treatment planning involves three basic steps: (1) a procedure must be devised that will provide the most relevant information, (2) the procedure must be applied and (3) the resulting information must be translated into a definition of the optimum implementation. There are varying degrees of treatment planning that may be implemented in internal emitter therapy. As in chemotherapy, the information from a Phase 1 study may be used to treat patients based upon body surface area. If treatment planning is included on a patient-specific basis, a pretherapy, trace-labeled, administration of the radiopharmaceutical is generally required. The data collected following the tracer dose may range from time-activity curves of blood and whole-body for use in blood, marrow or total body absorbed dose estimation to patient imaging for three-dimensional internal emitter dosimetry. The most ambitious approach requires a three-dimensional set of images representing radionuclide distribution (SPECT or PET) and a corresponding set of images representing anatomy (CT or MRI). The absorbed dose (or dose-rate) distribution may be obtained by convolution of a point kernel with the radioactivity distribution or by direct Monte Carlo calculation. A critical requirement for both techniques is the development of an overall structure that makes it possible, inmore »
- Authors:
-
- Memorial Sloan-Kettering Cancer Center, New York, NY (United States)
- Publication Date:
- Research Org.:
- Oak Ridge Associated Universities, TN (United States)
- Sponsoring Org.:
- National Insts. of Health, Bethesda, MD (United States); USDOE, Washington, DC (United States)
- OSTI Identifier:
- 684481
- Report Number(s):
- ORISE-99-0164-Vol.1; CONF-960536-PROC.-Vol.1
ON: DE99002903; TRN: IM9943%%172
- DOE Contract Number:
- FG02-86ER60407
- Resource Type:
- Conference
- Resource Relation:
- Conference: 6. international radiopharmaceutical dosimetry symposium, Gatlinburg, TN (United States), 7-10 May 1996; Other Information: PBD: Jan 1999; Related Information: Is Part Of Sixth international radiopharmaceutical dosimetry symposium: Proceedings. Volume 1; S.-Stelson, A.T. [ed.] [comp.]; Stabin, M.G.; Sparks, R.B. [eds.]; Smith, F.B. [comp.]; PB: 386 p.
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIOTHERAPY; DOSIMETRY; RADIATION DOSES; PLANNING; RADIATION DOSE DISTRIBUTIONS
Citation Formats
Sgouros, G. Treatment planning for internal emitter therapy: Methods, applications and clinical implications. United States: N. p., 1999.
Web.
Sgouros, G. Treatment planning for internal emitter therapy: Methods, applications and clinical implications. United States.
Sgouros, G. 1999.
"Treatment planning for internal emitter therapy: Methods, applications and clinical implications". United States. https://www.osti.gov/servlets/purl/684481.
@article{osti_684481,
title = {Treatment planning for internal emitter therapy: Methods, applications and clinical implications},
author = {Sgouros, G},
abstractNote = {Treatment planning involves three basic steps: (1) a procedure must be devised that will provide the most relevant information, (2) the procedure must be applied and (3) the resulting information must be translated into a definition of the optimum implementation. There are varying degrees of treatment planning that may be implemented in internal emitter therapy. As in chemotherapy, the information from a Phase 1 study may be used to treat patients based upon body surface area. If treatment planning is included on a patient-specific basis, a pretherapy, trace-labeled, administration of the radiopharmaceutical is generally required. The data collected following the tracer dose may range from time-activity curves of blood and whole-body for use in blood, marrow or total body absorbed dose estimation to patient imaging for three-dimensional internal emitter dosimetry. The most ambitious approach requires a three-dimensional set of images representing radionuclide distribution (SPECT or PET) and a corresponding set of images representing anatomy (CT or MRI). The absorbed dose (or dose-rate) distribution may be obtained by convolution of a point kernel with the radioactivity distribution or by direct Monte Carlo calculation. A critical requirement for both techniques is the development of an overall structure that makes it possible, in a routine manner, to input the images, to identify the structures of interest and to display the results of the dose calculations in a clinically relevant manner. 52 refs., 4 figs., 1 tab.},
doi = {},
url = {https://www.osti.gov/biblio/684481},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}