Nuclear Medicine Program progress report for quarter ending September 30, 1992
The radioiodination and in vivo evaluation of p-iodocaramiphen a muscarinic antagonist which binds with high affinity to the M[sub 1] receptor subtype in vitro are described. Biodistribution studies in female Fischer rats demonstrated that [[sup 125]I]-piodocaraminphen had significant cerebral localization, but the uptake did not demonstrate specific uptake in those cerebral regions rich in muscarinic receptors, and radioactivity washed out rapidly from the brain. In addition there was no significant blockage of activity when the rats were preinjected with quinuclidinyl benzilate. These results suggest that p-iodocaramiphen is not a good candidate for the in vivo study of M[sub 1] muscarinic receptor populations by SPECT. Because of the widespread interest and expected importance of the availability of large amounts of tungsten-188 required for the tungsten-188/rhenium-188 generator systems, we have investigated the large-scale production of tungsten-188 in the ORNL HFIR. We have also compared our production data with the theoretical production values and with experimental data available in the literature from other reactors. Tungsten-188 is produced in a fission nuclear reactor by double neutron capture of tungsten-186. The experimental yield of tungsten-188 is approximately 4 mCi/mg of tungsten-186 at the end of bombardment (EOB) in the HFIR operating at 85 MWt power for a one cycle irradiation ([approximately]21 days) at a thermal neutron flux of 2 [times] 10[sup 15] n.s[sup [minus]1]cm[sup [minus]2].
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6821014
- Report Number(s):
- ORNL/TM-1222; ON: DE93003548
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PARASYMPATHOLYTICS
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
TUNGSTEN 188
RADIOISOTOPE GENERATORS
BRAIN
CEREBELLUM
CEREBRUM
HEART
IODINE 125
KIDNEYS
LIVER
LUNGS
NUCLEAR MEDICINE
PROGRESS REPORT
RATS
RHENIUM 188
THYROID
TISSUE DISTRIBUTION
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-EVEN NUCLEI
GLANDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RHENIUM ISOTOPES
RODENTS
SYNTHESIS
TUNGSTEN ISOTOPES
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)