Oncogenic action of beta, proton, alpha and electron radiation on the rat skin

Technical Report · Tue Jan 01 00:00:00 EST 1980

DOI:https://doi.org/10.2172/6817302· OSTI ID:6817302

Burns, F. J.

Rat skin is being utilized as an empirical model for testing dose and time related aspects of the oncogenic action of ionizing radiation, ultraviolet light, and polycyclic aromatic hydrocarbons. Molecular lesions in the skin DNA, including, strand breaks and thymine dimers, are being measured and compared to tumor induction. The induction and repair kinetics of molcular lesions are being compared to split dose repair. Modifiers and radiosensitizers are being utilized to test specific aspects of a chromosome breakage theory of radiation oncogenesis.

• Research Organization: New York Univ., NY (USA). Dept. of Environmental Medicine
• DOE Contract Number: AS02-76EV03380
• OSTI ID: 6817302
• Report Number(s): COO-3380-33; TRN: 81-000460
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA PARTICLES
BIOLOGICAL REPAIR
CARCINOGENESIS
RADIOINDUCTION
STRAND BREAKS
BETA PARTICLES
BIOLOGICAL MODELS
DOSE-RESPONSE RELATIONSHIPS
CHROMOSOME BREAKAGE
DNA
ELECTRONS
ONCOGENIC TRANSFORMATIONS
POLYCYCLIC AROMATIC HYDROCARBONS
PROTEINS
SKIN
BIOLOGICAL RADIATION EFFECTS
ULTRAVIOLET RADIATION
DIMERS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIZERS
RATS
SPATIAL DOSE DISTRIBUTIONS
TEMPORAL DOSE DISTRIBUTIONS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
CHARGED PARTICLES
CHROMOSOMAL ABERRATIONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
HYDROCARBONS
LEPTONS
MAMMALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
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