Biodistribution of Ru-97-labeled DTPA, DMSA and transferrin. [Diagnostic potential]
Ruthenium-97 is being produced at the Brookhaven Linac Isotope Producer (BLIP). The favorable physical properties of Ru-97 and chemical reactivity of ruthenium offer a potential for using this isotope to label compounds useful for delayed scanning. Diethylenetriamine pentaacetic acid (DTPA), 2,3-Dimercaptosuccinic acid (DMSA), and Transferrin (TF) were labeled with Ru-97-chloride. Ru-97-DTPA and In-111-DTPA, injected intravenously, showed similar organ distribution, kinetics, and more than 80% excretion by 0.5 h. Ru-97-DTPA and In-111-DTPA injected into the cisterna magna of dogs showed similar kinetics in brain, blood, and urinary bladder. The energy deposited by 1 mCi In-111-DTPA is twice that from 1 mCi Ru-97-DTPA. High quality camera images of the CSF space in the dog were obtained with both isotopes. Ru-97-DMSA was prepared with and without the addition of SnCl/sub 2/.2H/sub 2/O. Tin-free DMSA was rapidly excreted via the kidneys, whereas for maximum cortical deposition, the tin-containing preparation was superior. This compound is suitable for delayed imaging of both normal and impaired kidneys. Tissue distribution studies were performed in abscess-bearing rats with Ru-97-transferrin. Although blood levels were higher than with Ga-67-citrate, the abscess had twice as much Ru-97-TF as Ga-67-citrate and the Ru-97 muscle activity was one-third that of Ga-67. Imaging of abscess-bearing rabbits with Ru-97-TF visualized the abscesses as early as 1/2 hr after injection. Since the initial images visualize the abscess so clearly and since the TF portion of the compound binds to the abscess, Tc-99m-TF is being studied for the same purpose. Ru-97-labeled compounds are a promising replacement for In-111 and possibly also for Ga-67 compounds with the advantages of lower radiation dose and high quality image. (ERB)
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); State Univ. of New York, Stony Brook (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6791596
- Report Number(s):
- BNL-28402; CONF-801082-4; TRN: 81-001372
- Resource Relation:
- Conference: ORAU radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 6 Oct 1980
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARBOXYLIC ACID ESTERS
LABELLING
RADIOPHARMACEUTICALS
DTPA
CHEMICAL PREPARATION
RUTHENIUM 97
RADIOCHEMISTRY
TRANSFERRIN
BLADDER
RADIONUCLIDE KINETICS
BLOOD
BRAIN
COMPARATIVE EVALUATIONS
EXCRETION
METABOLISM
TISSUE DISTRIBUTION
SCINTISCANNING
SPINAL CORD
KIDNEYS
BIOLOGICAL LOCALIZATION
ABSCESSES
DIAGNOSIS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
HALIDES
HALOGEN COMPOUNDS
INDIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
RUTHENIUM ISOTOPES
SYNTHESIS
TIN COMPOUNDS
TIN HALIDES
URINARY TRACT
VERTEBRATES
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550601 - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials