A method for the assessment of specific energy distribution in a model tumor system
Due to the short range of alpha particles in tissue, the calculation of dose from internally deposited alpha emitters requires a detailed analysis of the microscopic distribution of the radionuclide in order to determine the spatial distribution of energy emission events and, from this, the spatial distribution of dose. In the present study, the authors used quantitative autoradiography (QAR) to assess the microdistribution of a radiolabeled monoclonal antibody (MAb) fragment in human glioma xenografts in mice.
- Research Organization:
- North Carolina Univ., Dept. of Environmental Sciences and Engineering, Chapel Hill, NC (United States)
- Sponsoring Organization:
- USDOE Assistant Secretary for Environment, Safety, and Health, Washington, DC (United States)
- DOE Contract Number:
- AC05-76OR00033
- OSTI ID:
- 672127
- Report Number(s):
- DOE/OR/00033-T734; ON: DE97053611; TRN: 99:000325
- Resource Relation:
- Other Information: TH: Thesis (M.S.); PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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