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Title: A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT

Abstract

Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contribution of each type of radiation varies with depth in tissue. Because each of these radiations has its own RBE, and the RBE of the fast neutron component will not be constant as the neutron spectrum changes with depth, the problem of predicting the severity of the biological effect, in depth, becomes complex indeed. In order to attack this problem, Monte Carlo calculations of dose, checked against benchmark measurements, are employed. Two approaches are then used to assess the severity of the effect. In the first, the effective dose (D[sub EF]) is determined by summing the products of (D[center dot]RBE) for each radiation. The other approach involves placing cells at the location for which the D[sub EF] was calculated. Using a dose-response curvefrom a low-LET radiation, e.g. [supmore » 137]Cs gamma rays (D[sub [gamma]Ca]), the photon equivalent dose (PED, or D[sub P]) can be determined. If the RBE values used are correct, the D[sub EF] and the D[sub P] should be essentially identical.« less

Authors:
 [1]; ; ;  [2]
  1. Brookhaven National Lab., Upton, NY (United States) University Hospital, Stony Brook, NY (United States). Dept. of Radiation Oncology
  2. Brookhaven National Lab., Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY (United States)
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
6695440
Report Number(s):
BNL-48322; CONF-9209280-8
ON: DE93006646
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Conference
Resource Relation:
Conference: Neutron capture therapy for cancer, Columbus, OH (United States), 13-17 Sep 1992
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; NEUTRON CAPTURE THERAPY; NEUTRON DOSIMETRY; BORON; MONTE CARLO METHOD; PHANTOMS; RBE; CALCULATION METHODS; DOSIMETRY; ELEMENTS; MEDICINE; MOCKUP; NEUTRON THERAPY; NUCLEAR MEDICINE; RADIOLOGY; RADIOTHERAPY; SEMIMETALS; STRUCTURAL MODELS; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560101 - Biomedical Sciences, Applied Studies- Radiation Effects- Dosimetry & Monitoring- (1992-)

Citation Formats

Laster, B H, Liu, H B, Gordon, C R, and Bond, V P. A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT. United States: N. p., 1992. Web.
Laster, B H, Liu, H B, Gordon, C R, & Bond, V P. A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT. United States.
Laster, B H, Liu, H B, Gordon, C R, and Bond, V P. 1992. "A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT". United States. https://www.osti.gov/servlets/purl/6695440.
@article{osti_6695440,
title = {A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT},
author = {Laster, B H and Liu, H B and Gordon, C R and Bond, V P},
abstractNote = {Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contribution of each type of radiation varies with depth in tissue. Because each of these radiations has its own RBE, and the RBE of the fast neutron component will not be constant as the neutron spectrum changes with depth, the problem of predicting the severity of the biological effect, in depth, becomes complex indeed. In order to attack this problem, Monte Carlo calculations of dose, checked against benchmark measurements, are employed. Two approaches are then used to assess the severity of the effect. In the first, the effective dose (D[sub EF]) is determined by summing the products of (D[center dot]RBE) for each radiation. The other approach involves placing cells at the location for which the D[sub EF] was calculated. Using a dose-response curvefrom a low-LET radiation, e.g. [sup 137]Cs gamma rays (D[sub [gamma]Ca]), the photon equivalent dose (PED, or D[sub P]) can be determined. If the RBE values used are correct, the D[sub EF] and the D[sub P] should be essentially identical.},
doi = {},
url = {https://www.osti.gov/biblio/6695440}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1992},
month = {Wed Jan 01 00:00:00 EST 1992}
}

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