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Title: [Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, October 1, 1988--June 1, 1989

Abstract

The primary goal of this study is to achieve a more thorough understanding of the mechanisms employed by higher organisms to repair DNA damage induced by both ionizing and nonionizing radiation. These studies are also contributing to an improved understanding of the processes of mutagenesis and carcinogenesis in higher eukaryotes. The studies employ Drosophila as a model organism for investigating repair functions that are common to all higher eukaryotes. Drosophila was chosen in the early phases of this study primarily because of the ease with which one can isolate and characterize repair-deficient mutants in a metazoan organism. The laboratory has gone on to investigate the metabolic defects of such mutants while others have performed complementary genetic and cytogenetic studies which relate DNA repair processes to mutagenesis and chromosome stability. The repair studies have exploited the capacity to introduce mutant Drosophila cells into tissue culture and thereby compare repair defects directly with those of homologous human disorders. Researchers are currently employing recombinant DNA technology to investigate the mechanisms of the DNA repair pathways defined by those mutants.

Publication Date:
Research Org.:
Univ. of California, Davis, CA (United States)
Sponsoring Org.:
USDOE Office of Energy Research, Washington, DC (United States)
OSTI Identifier:
663535
Report Number(s):
DOE/ER/60538-T3
ON: DE98007381; TRN: AHC29818%%372
DOE Contract Number:  
FG03-87ER60538
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1989]
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; PROGRESS REPORT; DROSOPHILA; DNA REPAIR; RECOMBINANT DNA; STRAND BREAKS; MUTAGENESIS; CARCINOGENESIS; BIOLOGICAL PATHWAYS; DNA-CLONING

Citation Formats

. [Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, October 1, 1988--June 1, 1989. United States: N. p., 1989. Web. doi:10.2172/663535.
. [Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, October 1, 1988--June 1, 1989. United States. https://doi.org/10.2172/663535
. 1989. "[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, October 1, 1988--June 1, 1989". United States. https://doi.org/10.2172/663535. https://www.osti.gov/servlets/purl/663535.
@article{osti_663535,
title = {[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, October 1, 1988--June 1, 1989},
author = {},
abstractNote = {The primary goal of this study is to achieve a more thorough understanding of the mechanisms employed by higher organisms to repair DNA damage induced by both ionizing and nonionizing radiation. These studies are also contributing to an improved understanding of the processes of mutagenesis and carcinogenesis in higher eukaryotes. The studies employ Drosophila as a model organism for investigating repair functions that are common to all higher eukaryotes. Drosophila was chosen in the early phases of this study primarily because of the ease with which one can isolate and characterize repair-deficient mutants in a metazoan organism. The laboratory has gone on to investigate the metabolic defects of such mutants while others have performed complementary genetic and cytogenetic studies which relate DNA repair processes to mutagenesis and chromosome stability. The repair studies have exploited the capacity to introduce mutant Drosophila cells into tissue culture and thereby compare repair defects directly with those of homologous human disorders. Researchers are currently employing recombinant DNA technology to investigate the mechanisms of the DNA repair pathways defined by those mutants.},
doi = {10.2172/663535},
url = {https://www.osti.gov/biblio/663535}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Dec 31 00:00:00 EST 1989},
month = {Sun Dec 31 00:00:00 EST 1989}
}