(Development of Bromine-77 from the LAMPF facility)

Technical Report · Sun Jan 01 00:00:00 EST 1989

DOI:https://doi.org/10.2172/6634477· OSTI ID:6634477

The objective of the work was to conduct the necessary studies required to evaluate the efficacy, potential benefit and role of bromine-77 labeled steroids in the detection and evaluation of treatment for hormone-dependent tumors. This report presents progress on the following tasks: An initial investigation concentrating on the radiobromination at carbon-6 or carbon-7 in selected simple steroids utilizing the nuclides, bromine-82 and bromine-77, analytical spectroscopy of radiolabeled compounds, and investigating the biodistribution, toxicology and tumor affinity of labeled agents.

• Research Organization: New Mexico Univ., Albuquerque, NM (USA). Dept. of Radiology
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AS04-81EV10596
• OSTI ID: 6634477
• Report Number(s): DOE/EV/10596-T6; ON: DE91000117
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ESTRADIOL
HALOGENATION
LABELLED COMPOUNDS
SYNTHESIS
NEOPLASMS
RADIOTHERAPY
STEROIDS
LABELLING
AFFINITY
BROMINE 77
BROMINE 82
DETECTION
LIQUID COLUMN CHROMATOGRAPHY
PROGRESS REPORT
RADIATION DETECTORS
RADIOPHARMACEUTICALS
SPECTROSCOPY
X-RAY DIFFRACTOMETERS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
CHEMICAL REACTIONS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DIFFRACTOMETERS
DISEASES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTRANES
ESTROGENS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MEASURING INSTRUMENTS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOLOGY
SEPARATION PROCESSES
STEROID HORMONES
THERAPY
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550201 - Biochemistry- Tracer Techniques
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)