In vivo monitoring of heavy metals in man: cadmium and mercury
Direct in vivo measurements of selected heavy metals is possible by nuclear analytical techniques. In particular, cadmium and mercury are retained in the body in sufficient quantities for their detection by neutron activation analysis. Autopsy data on cadmium of adult male non-smokers living in the US indicates an average body burden of 30 mg by age 50. The distribution of cadmium in the body, however, is nonuniform, approximately 50% being located in the kidneys and liver. The increased concentration of cadmium within these organs has made possible the direct in vivo measurements of this metal by prompt-gamma neutron activation analysis (PGNAA). At present, in vivo determinations of mercury have been performed on phantoms only. These in vivo techniques provide a unique method of obtaining accurate organ burden data in humans that can be related to the toxicological effects of these metals.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6528975
- Report Number(s):
- BNL-32243; CONF-8210106-2; ON: DE83005148
- Resource Relation:
- Conference: Workshop on uses of nuclear analytical methods in metal toxicology, Upton, NY, USA, 11 Oct 1982; Other Information: Portions are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CADMIUM
ACTIVATION ANALYSIS
BIOLOGICAL ACCUMULATION
MERCURY
AUTOPSY
BODY BURDEN
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
IN VIVO
INDUSTRIAL MEDICINE
KIDNEYS
LIVER
MONITORING
NEUTRON REACTIONS
PHANTOMS
BARYON REACTIONS
BODY
CHEMICAL ANALYSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HADRON REACTIONS
MEDICINE
METALS
MOCKUP
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANS
STRUCTURAL MODELS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
400101 - Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures