Genotoxic effects of sunlight-activated waste waters
Natural sunlight induces a genotoxic response in cultured CHO cells pre-treated with shale oil retort process water. Near ultraviolet light (NUV) component of the solar spectrum is the apparent radiation responsible for photoactivation. Cultured human skin fibroblasts are acutely sensitive to the genotoxic effects of photoactivated process water. The mutagenic potential of photoactivated process water in human cells is the same as that witnessed for an equivalent killing dose of the potent skin carcinogen FUV. DNA repair processes are involved in modulating genotoxic effects of this photo-induced process. The exact magnitude of the potential health-related and environmental risks resulting from photoactivation of retort process waters and other oil shale by-products is unassessed at this time. Our demonstration that a significant rate of mutation occurs in cultured human cells exposed to high dilutions of process waters and fluences of NUV comparable to that encountered during nominal exposure to sunlight suggests that such assessment is a prerequisite to minimal risk development of our oil shale resources.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6527409
- Report Number(s):
- LA-UR-81-986; CONF-810357-1
- Resource Relation:
- Conference: 7. FDA's science symposium on photochemical toxicity, Bethesda, MA, USA, 16 Mar 1981
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sunlight activation of shale-oil byproducts as measured by genotoxic effects in cultured Chinese hamster cells
Cytotoxic and mutagenic properties of shale oil byproducts. I. Activation of retort process waters with near ultraviolet light
Related Subjects
04 OIL SHALES AND TAR SANDS
ANIMAL CELLS
MUTAGENESIS
FIBROBLASTS
RETORTING
ENVIRONMENTAL IMPACTS
HEALTH HAZARDS
WASTE WATER
GENETIC EFFECTS
BIOLOGICAL REPAIR
CELL CULTURES
DNA
EPITHELIUM
NEAR ULTRAVIOLET RADIATION
OIL SHALES
PHOTOCHEMICAL REACTIONS
PHOTOREACTIVATION
SYNERGISM
TOXICITY
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DECOMPOSITION
ELECTROMAGNETIC RADIATION
ENERGY SOURCES
FOSSIL FUELS
FUELS
HAZARDS
HYDROGEN COMPOUNDS
LIQUID WASTES
MATERIALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
TISSUES
ULTRAVIOLET RADIATION
WASTES
WATER
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
040700 - Oil Shales & Tar Sands- Health & Safety
560121 - Radiation Effects on Cells- External Source- (-1987)