Mechanisms for radiation damage in DNA. Progress report, January 1, 1980-December 31, 1980
In this project several mechanisms are proposed for radiation damage to DNA constituents and DNA, and a series of experiments detailed utilizing electron spin resonance spectrometry to test the proposed mechanisms. Under current investigation are irradiated systems of DNA constituents which may shed light on indirect effects. In addition, studies of radiation effects on lipids have been undertaken which will shed light on the only other proposed site for cell kill, the membrane. Studies completed during the past year are: (1) ..pi.. cations produced in DNA bases by attack of oxidizing radicals; (2) INDO studies of radicals produced in peptides and carboxylic acid model compounds; (3) electron reactions with carboxylic acids, ketones and aldehydes; and (4) ..gamma..-irradiation of esters and triglycerides. Progress has been made this year in a study of radicals generated in model compounds for the sugar-phosphate backbone.
- Research Organization:
- Oakland Univ., Rochester, MI (USA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AS02-76EV02364
- OSTI ID:
- 6501243
- Report Number(s):
- DOE/EV/02364-T1; COO-2364-18; TRN: 81-010724
- Country of Publication:
- United States
- Language:
- English
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Mechanisms for radiation damage in DNA. Progress report, January 1, 1982-December 31, 1982
Mechanisms for radiation damage in DNA. Progress report
Related Subjects
DNA
RADIATION INJURIES
HYDROXYL RADICALS
CHEMICAL REACTIONS
CATIONS
CELL MEMBRANES
ELECTRON SPECTROSCOPY
ELECTRON SPIN RESONANCE
LIPIDS
RESEARCH PROGRAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CONSTITUENTS
CHARGED PARTICLES
INJURIES
IONS
MAGNETIC RESONANCE
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADICALS
RESONANCE
SPECTROSCOPY
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)