Synthesis and evaluation of boron compounds for neutron capture therapy of malignant brain tumors
Boron neutron capture therapy offers the potentiality for treating brain tumors currently resistant to treatment. The success of this form of therapy is directly dependent upon the delivery of sufficient numbers of thermal-neutrons to tumor cells which possess high concentrations of B-10. The objective of this project is to develop chemical methodology to synthesize boron-containing compounds with the potential for becoming incorporated into rapidly-dividing malignant brain tumor cells and excluded from normal components of the brain and surrounding tissues, to develope biological methods for assessing the potential of the compound by use of cell culture or intratumoral injection, to develop analytical methodology for measuring boron in cells and tissue using direct current plasma atomic emission spectroscopy (DCP-AES) and alpha track autoradiography, to develop biochemical and HPLC procedures for evaluating compound uptake and tissue half-life, and to develop procedures required to assess both in vitro and vivo efficacy of BNCT with selected compounds.
- Research Organization:
- Ohio State Univ. Research Foundation, Columbus, OH (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-90ER60972
- OSTI ID:
- 6375527
- Report Number(s):
- DOE/ER/60972-3; ON: DE93015880
- Country of Publication:
- United States
- Language:
- English
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37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
GLIOMAS
NEUTRON THERAPY
NUCLEOSIDES
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BORON COMPOUNDS
CELL CULTURES
EXPERIMENTAL NEOPLASMS
PROGRESS REPORT
RATS
URIDINE
ANIMALS
AZINES
DISEASES
DOCUMENT TYPES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOLOGY
RADIOTHERAPY
RIBOSIDES
RODENTS
SYNTHESIS
THERAPY
URACILS
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation