Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation

Technical Report · Mon Oct 01 00:00:00 EDT 1990

DOI:https://doi.org/10.2172/6365510· OSTI ID:6365510

Elkind, M M; Bedford, J; Benjamin, S A; Waldren, C A ^[1]; Gotchy, R L ^[2]

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1. Colorado State Univ., Fort Collins, CO (USA)
2. Science Applications International Corp., McLean, VA (USA)

A study was undertaken by five radiation scientists to examine the feasibility of reducing the uncertainties in the estimation of risk due to protracted low doses of ionizing radiation. In addressing the question of feasibility, a review was made by the study group: of the cellular, molecular, and mammalian radiation data that are available; of the way in which altered oncogene properties could be involved in the loss of growth control that culminates in tumorigenesis; and of the progress that had been made in the genetic characterizations of several human and animal neoplasms. On the basis of this analysis, the study group concluded that, at the present time, it is feasible to mount a program of radiation research directed at the mechanism(s) of radiation-induced cancer with special reference to risk of neoplasia due to protracted, low doses of sparsely ionizing radiation. To implement a program of research, a review was made of the methods, techniques, and instruments that would be needed. This review was followed by a survey of the laboratories and institutions where scientific personnel and facilities are known to be available. A research agenda of the principal and broad objectives of the program is also discussed. 489 refs., 21 figs., 14 tabs.

• Research Organization: Nuclear Regulatory Commission, Washington, DC (USA). Div. of Regulatory Applications; Science Applications International Corp., McLean, VA (USA)
• Sponsoring Organization: USNRC
• OSTI ID: 6365510
• Report Number(s): NUREG/CR-5635; ON: TI91002485; TRN: 91-001626
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL RADIATION EFFECTS
HUMAN POPULATIONS
BIOLOGICAL EFFECTS
CARCINOGENESIS
FEASIBILITY STUDIES
GENETIC RADIATION EFFECTS
LOW DOSE IRRADIATION
MOLECULAR BIOLOGY
MUTAGENESIS
NEOPLASMS
ONCOGENES
ONCOGENIC TRANSFORMATIONS
RADIATION HAZARDS
RESEARCH PROGRAMS
CELL TRANSFORMATIONS
DISEASES
GENES
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
IRRADIATION
PATHOGENESIS
POPULATIONS
RADIATION EFFECTS
560100* - Biomedical Sciences
Applied Studies- Radiation Effects
550600 - Medicine