Biological dosimetry: Mechanistic concepts

Conference · Mon Jan 01 00:00:00 EST 1990

OSTI ID:6365082

Preston, R J

The study of the induction of chromosome aberrations by ionizing radiations has a 50 year history, having its initiation in the pioneering work of Karl Sax. Lea and his colleagues provided a more mathematical description of dose response curves and the effects of split doses, that allowed for the development of studies to better understand the process by which radiation induced chromosome aberrations. Subsequent studies have refined our understanding of the mechanism of induction, but many of the questions raised by these original studies still remain unanswered. It is the intention of this short review to revisit some of the questions pertinent to the mechanism of induction of chromosome aberrations and provide a personal view of what I think is happening. 19 refs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOD; DOE/ER
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6365082
• Report Number(s): CONF-9011134-1; ON: DE91002654
• Resource Relation: Conference: 1. international conference on biological dosimetry, Madrid (Spain), 29 Nov - 5 Dec 1990
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
MAN
BIOLOGICAL RADIATION EFFECTS
CHROMOSOME BREAKAGE
CHRONIC EXPOSURE
DNA
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
LET
LYMPHOCYTES
MATHEMATICAL MODELS
RADIATION DOSES
RADIATION HAZARDS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOSES
ENERGY TRANSFER
HAZARDS
HEALTH HAZARDS
LEUKOCYTES
MAMMALS
MATERIALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
RADIATION EFFECTS
RECOVERY
REPAIR
SOMATIC CELLS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture