Synthesis and in-vivo detection of boronated compounds for use in BNCT

Technical Report · Fri Feb 01 00:00:00 EST 1991

DOI:https://doi.org/10.2172/6296640· OSTI ID:6296640

Kabalka, G W

The primary objectives of the DOE Program at the University of Tennessee Biomedical Imaging Center are the development of new boron-neutron-capture agents as well as the technology to detect boron compounds in-vivo. The detection technology focuses on the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring BNCT agents in-vivo. A significant portion of the effort is directed toward the design of boron-containing neutron-capture-therapy agents. The UT -- DOE program is unique in that it has access to two state-of-the-art multinuclear magnetic resonance imaging units housed in the Biomedical Imaging Center at the University of Tennessee Medical Center at Knoxville. In addition the UT -- DOE researchers actively collaborate with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory and Oak Ridge Associated Universities). An important goal of the DOE program at UT is to provide training for students (predoctoral and postdoctoral). The University of Tennessee is one of the very few institutions in the world where students have hands-on'' access to both modern scientific equipment and medical imaging modalities such as the clinical MRI units. The academic nature of the program facilitates collaborative interactions with other DOE programs and helps to insure the continued availability of skilled scientists dedicated to the advancement of diagnostic medical procedures. 14 refs., 3 figs.

• Research Organization: Tennessee Univ. Hospital, Knoxville, TN (USA). Dept. of Radiology
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG05-89ER60892
• OSTI ID: 6296640
• Report Number(s): DOE/ER/60892-2; ON: DE91007528
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
BORON COMPOUNDS
CHEMICAL PREPARATION
RADIOPHARMACEUTICALS
BIOCHEMICAL REACTION KINETICS
BORON 10
BORON 11
CARBORANES
GADOLINIUM
IN VIVO
LABELLED COMPOUNDS
LIPOSOMES
NEOPLASMS
NEUTRON CAPTURE THERAPY
NMR IMAGING
NMR SPECTRA
PROGRESS REPORT
US DOE
BORON ISOTOPES
CARBON COMPOUNDS
CELL CONSTITUENTS
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DRUGS
ELEMENTS
ISOTOPES
KINETICS
LIGHT NUCLEI
MEDICINE
METALS
NATIONAL ORGANIZATIONS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
ORGANOIDS
RADIOLOGY
RADIOTHERAPY
RARE EARTHS
REACTION KINETICS
SPECTRA
STABLE ISOTOPES
SYNTHESIS
THERAPY
US ORGANIZATIONS
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550602 - Medicine- External Radiation in Diagnostics- (1980-)