Endogenous retrovirus and radiation-induced leukemia in the RMF mouse

Conference · Fri Jan 01 00:00:00 EST 1982

OSTI ID:6251967

Tennant, R W; Boone, L R; Lalley, P; Yang, W K

The induction of myeloid leukemia in irradiated RFM/Un mice has been associated with retrovirus infection. However, two characteristics of this strain complicate efforts to define the role of the virus. This strain possesses only one inducible host range class of endogenous virus and a unique gene, in addition to the Fv-1/sup n/ locus, which specifically restricts exogenous infection by endogenous viruses. These characteristics possibly account for absence of recombinant viruses in this strain, even though virus is amply expressed during most of the animal's life span. We have examined further the distribution of retrovirus sequences and the chromosomal locus of the inducible virus in this strain. This report describes evidence for additional viral sequences in cells of a radiation-induced myeloid leukemia line and discusses the possible origin of these added copies.

• Research Organization: National Inst. of Environmental Health Sciences, Research Triangle Park, NC (USA); Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6251967
• Report Number(s): CONF-820439-7; ON: DE83012061
• Resource Relation: Conference: Symposium on genetic mechanisms of carcinogenesis, Gatlinburg, TN, USA, 11 Apr 1982; Other Information: Portions are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
LEUKEMIA VIRUSES
LEUKEMIA
RADIOINDUCTION
GENETIC MAPPING
INFECTIVITY
MICE
ANIMALS
DISEASES
HEMIC DISEASES
MAMMALS
MAPPING
MICROORGANISMS
NEOPLASMS
ONCOGENIC VIRUSES
PARASITES
RODENTS
VERTEBRATES
VIRUSES
560121* - Radiation Effects on Cells- External Source- (-1987)