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Title: Traversal of cells by radiation and absorbed fraction estimates for electrons and alpha particles

Abstract

Consideration of the pathlength which radiation traverses in a cell is central to algorithms for estimating energy deposition on a cellular level. Distinct pathlength distributions occur for radionuclides: (1) uniformly distributed in space about the cell (referred to as -randomness); (2) uniformly distributed on the surface of the cell (S-randomness); and (3) uniformly distributed within the cell volume (I-randomness). For a spherical cell of diameter d, the mean pathlengths are 2/3d, 1/2d, and 3/4d, respectively, for these distributions. Algorithms for simulating the path of radiation through a cell are presented and the absorbed fraction in the cell and its nucleus are tabulated for low energy electrons and alpha particles emitted on the surface of spherical cells. The algorithms and absorbed fraction data should be of interest to those concerned with the dosimetry of radionuclide-labeled monoclonal antibodies. 8 refs., 3 figs., 2 tabs.

Authors:
; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
OSTI Identifier:
6232655
Report Number(s):
CONF-851113-4
ON: DE86006095
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Conference
Resource Relation:
Conference: Radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 5 Nov 1985; Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALPHA PARTICLES; DOSIMETRY; ELECTRONS; RADIOIMMUNOTHERAPY; SPATIAL DOSE DISTRIBUTIONS; MATHEMATICAL MODELS; CELL MEMBRANES; MONOCLONAL ANTIBODIES; ANTIBODIES; CELL CONSTITUENTS; CHARGED PARTICLES; ELEMENTARY PARTICLES; FERMIONS; IMMUNOLOGY; LEPTONS; MEDICINE; MEMBRANES; NUCLEAR MEDICINE; RADIATION DOSE DISTRIBUTIONS; RADIOIMMUNOLOGY; RADIOLOGY; RADIOTHERAPY; THERAPY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man

Citation Formats

Eckerman, K F, Ryman, J C, Taner, A C, and Kerr, G D. Traversal of cells by radiation and absorbed fraction estimates for electrons and alpha particles. United States: N. p., 1985. Web.
Eckerman, K F, Ryman, J C, Taner, A C, & Kerr, G D. Traversal of cells by radiation and absorbed fraction estimates for electrons and alpha particles. United States.
Eckerman, K F, Ryman, J C, Taner, A C, and Kerr, G D. 1985. "Traversal of cells by radiation and absorbed fraction estimates for electrons and alpha particles". United States. https://www.osti.gov/servlets/purl/6232655.
@article{osti_6232655,
title = {Traversal of cells by radiation and absorbed fraction estimates for electrons and alpha particles},
author = {Eckerman, K F and Ryman, J C and Taner, A C and Kerr, G D},
abstractNote = {Consideration of the pathlength which radiation traverses in a cell is central to algorithms for estimating energy deposition on a cellular level. Distinct pathlength distributions occur for radionuclides: (1) uniformly distributed in space about the cell (referred to as -randomness); (2) uniformly distributed on the surface of the cell (S-randomness); and (3) uniformly distributed within the cell volume (I-randomness). For a spherical cell of diameter d, the mean pathlengths are 2/3d, 1/2d, and 3/4d, respectively, for these distributions. Algorithms for simulating the path of radiation through a cell are presented and the absorbed fraction in the cell and its nucleus are tabulated for low energy electrons and alpha particles emitted on the surface of spherical cells. The algorithms and absorbed fraction data should be of interest to those concerned with the dosimetry of radionuclide-labeled monoclonal antibodies. 8 refs., 3 figs., 2 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/6232655}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}

Conference:
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