High-let radiation carcinogenesis

Conference · Fri Jan 01 00:00:00 EST 1982

OSTI ID:6219388

Fry, R J.M.; Powers-Risius, P; Alpen, E L; Ainsworth, E J; Ullrich, R L

Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20 to 30 rads.

• Research Organization: Oak Ridge National Lab., TN (USA); Lawrence Berkeley Lab., CA (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6219388
• Report Number(s): CONF-820582-8; ON: DE83012561
• Resource Relation: Conference: 24. COSPAR meeting (Committee on Space Research), Ottawa, Canada, 17 May 1982; Other Information: Microfiche only, copy does not permit paper copy reproduction
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
RADIOINDUCTION
LET
DOSE-RESPONSE RELATIONSHIPS
NEUTRON BEAMS
BIOLOGICAL RADIATION EFFECTS
MICE
NEUTRON DOSIMETRY
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
DOSIMETRY
ENERGY TRANSFER
MAMMALS
NUCLEON BEAMS
PARTICLE BEAMS
PATHOGENESIS
RADIATION EFFECTS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals