Computer analysis of HIV epitope sequences

Conference · Mon Jan 01 00:00:00 EST 1990

OSTI ID:6215378

Gupta, G; Myers, G

Phylogenetic tree analysis provide us with important general information regarding the extent and rate of HIV variation. Currently we are attempting to extend computer analysis and modeling to the V3 loop of the type 2 virus and its simian homologues, especially in light of the prominent role the latter will play in animal model studies. Moreover, it might be possible to attack the slightly similar V4 loop by this approach. However, the strategy relies very heavily upon natural'' information and constraints, thus there exist severe limitations upon the general applicability, in addition to uncertainties with regard to long-range residue interactions. 5 refs., 3 figs.

• Research Organization: Los Alamos National Lab., NM (USA)
• Sponsoring Organization: DOHHS
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6215378
• Report Number(s): LA-UR-90-3916; CONF-9010273-1; ON: DE91004847
• Resource Relation: Conference: 5. colloque des cent gardes, Paris (France), 29-31 Oct 1990
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
AIDS VIRUS
GENETIC VARIABILITY
AIDS
ANTIGENS
BIOLOGICAL MODELS
COMPUTERIZED SIMULATION
DNA SEQUENCING
FORECASTING
GENES
IMMUNOLOGY
MIGRATION
NUCLEIC ACIDS
BIOLOGICAL VARIABILITY
DISEASES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
MICROORGANISMS
ORGANIC COMPOUNDS
PARASITES
SIMULATION
STRUCTURAL CHEMICAL ANALYSIS
VIRAL DISEASES
VIRUSES
550700* - Microbiology
550400 - Genetics
570000 - Health & Safety