Structurally modified fatty acids - clinical potential as tracers of metabolism
Recently 15-p-iodophenyl-betamethyl-pentadecanoic acid (BMPPA) was proposed for myocardial scintigraphy, as possible probe of metabolic processes other than ..beta..-oxidation. In 19 patients myocardial scintigraphy was done after i.v. BMPPA (2 to 4 mCi). Data were collected (LAO 45/sup 0//14; anterior/5) for 100 minutes in the fasted patients. From heart (H) and liver (L) organ to background (BG) ratios were calculated, and the elimination (E) behavior was analyzed from BG (V. cava region) corrected time activity curves. In 10 patients plasma and urine were examined. By CHCl/sub 3//MeOH extraction of plasma samples (90 min. pi) both in water and in organic medium soluble catabolites were found. TLC fractionation showed that those were co-migrating, compared to standards, with benzoic acid, BMPPA and triglycerides. In urine (0 to 2h pi: 4.1% dose) hippuric acid was found. It is concluded that BMPPA is a useful agent for myocardial scintigraphy. Its longer retention in the heart compared to unbranched radioiodinated fatty acids may facilitate SPECT studies. Rate of elimination and plasma analysis indicate the metabolic breakdown of BMPPA. Yet, the complexity of the supposed mechanism may impede curve interpretation in terms of specific metabolic pathways. 19 refs., 5 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA); Vienna Univ. (Austria). 1. Medizinische Klinik; Oesterreichisches Forschungszentrum Seibersdorf G.m.b.H.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6170364
- Report Number(s):
- CONF-8510195-2; ON: DE86005161
- Resource Relation:
- Conference: Assessment of myocardial metabolism by cardiac imaging symposium, Vienna, Austria, 26 Oct 1985; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
MONOCARBOXYLIC ACIDS
DIAGNOSTIC USES
MYOCARDIUM
SCINTISCANNING
ORGANIC IODINE COMPOUNDS
METABOLISM
BIOLOGICAL HALF-LIFE
EXCRETION
PATIENTS
THIN-LAYER CHROMATOGRAPHY
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
HEART
MUSCLES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
SEPARATION PROCESSES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques