uv excision-repair gene transfer in Chinese hamster ovary (CHO) cells
Conference
·
OSTI ID:6150923
uvc-sensitive mutants of CHO cells provide a model system for molecular studies of DNA repair. We present our recent results which show that these mutants are competent recipients for plasmid marker gene transfer and incorporation of a putative CHO repair gene. The applicability and advantages of this system for interspecies human repair gene identification are discussed.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6150923
- Report Number(s):
- LA-UR-83-1076; CONF-830440-2; ON: DE83011323
- Resource Relation:
- Conference: UCLA symposia on molecular and cellular biology, Keystone, CO, USA, 10 Apr 1983
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL REPAIR
MOLECULAR BIOLOGY
DNA
ANIMAL CELLS
BIOLOGICAL MODELS
CELL CULTURES
GENES
HAMSTERS
MUTANTS
OVARIES
PLASMIDS
RADIOSENSITIVITY
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL RECOVERY
BODY
CELL CONSTITUENTS
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATIONS
RECOVERY
REPAIR
RODENTS
VERTEBRATES
550300* - Cytology
560121 - Radiation Effects on Cells- External Source- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL REPAIR
MOLECULAR BIOLOGY
DNA
ANIMAL CELLS
BIOLOGICAL MODELS
CELL CULTURES
GENES
HAMSTERS
MUTANTS
OVARIES
PLASMIDS
RADIOSENSITIVITY
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL RECOVERY
BODY
CELL CONSTITUENTS
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATIONS
RECOVERY
REPAIR
RODENTS
VERTEBRATES
550300* - Cytology
560121 - Radiation Effects on Cells- External Source- (-1987)