Analytical cytology applied to detection of induced cytogenetic abnormalities

Conference · Thu Aug 06 00:00:00 EDT 1987

OSTI ID:6026759

Gray, J W; Lucas, J; Straume, T; Pinkel, D

Radiation-induced biological damage results in formation of a broad spectrum of cytogenetic changes such as translocations, dicentrics, ring chromosomes, and acentric fragments. A battery of analytical cytologic techniques are now emerging that promise to significantly improve the precision and ease with which these radiation induced cytogenetic changes can be quantified. This report summarizes techniques to facilitate analysis of the frequency of occurrence of structural and numerical aberrations in control and irradiated human cells. 14 refs., 2 figs.

• Research Organization: Lawrence Livermore National Lab., CA (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6026759
• Report Number(s): UCRL-97276; CONF-870701-8; ON: DE88000785; TRN: 87-041330
• Resource Relation: Conference: 8. international congress of radiation research, Edinburgh, UK, 19 Jul 1987; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ACROCENTRIC CHROMOSOMES
CHROMOSOME SORTING
DICENTRIC CHROMOSOMES
RING CHROMOSOMES
ANEUPLOIDY
CHROMOSOME BREAKAGE
HEREDITARY DISEASES
RADIOBIOLOGY
BIOLOGY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DISEASES
MUTATIONS
PLOIDY
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550400 - Genetics
550200 - Biochemistry