Use of environmental health-risk analysis for managing toxic substances
Abstract
This paper presents a set of simple models used to assess health risks based on toxicity, environmental mobility and persistence. These models use a representative landscape in order to describe the steady-state distribution of arsenic, tritiated water, and TCDD as a result of continuous additions to soil. This information is used to assess potential exposures. Application of the screening model to three chemically different carcinogens reveals that the environmental health risk does not scale with direct measures of toxicity. As estimated here, the environmental health risk of TCDD relative to tritiated water and arsenic is roughly an order of magnitude less than its cancer potency relative to these compounds. The difference is attributable in large part to the immobility of TCDD relative to tritium and the lower persistence of TCDD compared to arsenic. The purpose is to present a simple procedure for using the relative behavior of toxic species under prototype conditions as a basis for risk management. 21 refs., 4 tabs. (ACR)
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Livermore National Lab., CA (USA)
- OSTI Identifier:
- 5862754
- Report Number(s):
- UCRL-92329; CONF-850612-1
ON: DE85008964
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Conference
- Resource Relation:
- Conference: Air Pollution Control Association annual meeting and exhibition, Detroit, MI, USA, 16 Jun 1985
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ARSENIC; HEALTH HAZARDS; DIOXIN; TRITIUM; RADIATION HAZARDS; CARCINOGENESIS; ENVIRONMENTAL EXPOSURE PATHWAY; MATHEMATICAL MODELS; RISK ASSESSMENT; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; ELEMENTS; HAZARDS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PATHOGENESIS; RADIOISOTOPES; SEMIMETALS; YEARS LIVING RADIOISOTOPES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
Citation Formats
McKone, T E. Use of environmental health-risk analysis for managing toxic substances. United States: N. p., 1985.
Web.
McKone, T E. Use of environmental health-risk analysis for managing toxic substances. United States.
McKone, T E. 1985.
"Use of environmental health-risk analysis for managing toxic substances". United States. https://www.osti.gov/servlets/purl/5862754.
@article{osti_5862754,
title = {Use of environmental health-risk analysis for managing toxic substances},
author = {McKone, T E},
abstractNote = {This paper presents a set of simple models used to assess health risks based on toxicity, environmental mobility and persistence. These models use a representative landscape in order to describe the steady-state distribution of arsenic, tritiated water, and TCDD as a result of continuous additions to soil. This information is used to assess potential exposures. Application of the screening model to three chemically different carcinogens reveals that the environmental health risk does not scale with direct measures of toxicity. As estimated here, the environmental health risk of TCDD relative to tritiated water and arsenic is roughly an order of magnitude less than its cancer potency relative to these compounds. The difference is attributable in large part to the immobility of TCDD relative to tritium and the lower persistence of TCDD compared to arsenic. The purpose is to present a simple procedure for using the relative behavior of toxic species under prototype conditions as a basis for risk management. 21 refs., 4 tabs. (ACR)},
doi = {},
url = {https://www.osti.gov/biblio/5862754},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Mar 01 00:00:00 EST 1985},
month = {Fri Mar 01 00:00:00 EST 1985}
}