New radiohalogenated alkenyl tellurium fatty acids
Radiolabeled long-chain fatty acids have diagnostic value as radiopharmaceutical tools in myocardial imaging. Some applications of these fatty acids are limited due to their natural metabolic degradation in vivo with subsequent washout of the radioactivity from the myocardium. The identification of structural features that will increase the myocardial residence time without decreasing the heart uptake of long-chain fatty acids is of interest. Fatty acids containing the tellurium heteroatom were the first modified fatty acids developed that show unique prolonged myocardial retention and low blood levels. Our detailed studies with radioiodinated vinyliodide substituted tellurium fatty acids demonstrate that heart uptake is a function of the tellurium position. New techniques of tellurium and organoborane chemistry have been developed for the synthesis of a variety of radioiodinated iodoalkenyl tellurium fatty acids. 9 refs., 3 figs., 2 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA); Tennessee Univ., Knoxville (USA). Dept. of Chemistry
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5823150
- Report Number(s):
- CONF-8708173-1; ON: DE88001767
- Resource Relation:
- Conference: 5. international symposium on the chemistry of selenium and tellurium, Oak Ridge, TN, USA, 24 Aug 1987; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MONOCARBOXYLIC ACIDS
LABELLING
TISSUE DISTRIBUTION
MYOCARDIUM
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TELLURIUM COMPOUNDS
CHEMICAL PREPARATION
BLOOD
HALOGENATION
HEART
IMAGE PROCESSING
IODINE 125
KIDNEYS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUNGS
OPTIMIZATION
ORGANOMETALLIC COMPOUNDS
RADIOPHARMACEUTICALS
RATS
SAMPLE PREPARATION
STRUCTURAL CHEMICAL ANALYSIS
TELLURIUM 123
THYROID
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
CHROMATOGRAPHY
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production