Measurements, in vivo, of parameters of the dopamine system

Conference · Sat Jan 01 00:00:00 EST 1983

OSTI ID:5820876

Friedman, A M; DeJesus, O T; Dinerstein, R; Revenaugh, J

This paper discusses methods of measuring important parameters of the dopamine system in the living animal by use of PET techniques. One primary concern is the density and binding affinity of post-synaptic neuroreceptors. A second concern is the activity of neurons. In vivo, this is generally related to the turnover of neurotransmitter and can also be related to the uptake of precursor compounds by the neurons. If the transmitter and neuroleptic compound compete for the same binding sites (on the receptor molecule) these two effects are interwoven and are not easily isolated. It appears that the movement of neuroleptic drugs from the brain is slow enough to allow equilibrium to be maintained between ligand and receptor, especially after some time for the initial washout and translocation in the brain. To test the consequences of equilibrium binding and the possible use of the model for measurement of receptor densities by emission tomography we have modified Clark's equilibrium model of ligand binding. In this note we will describe the solutions of the equations and some comparisons of the predictions of the model with data, as well as its application to tomographic measurements.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 5820876
• Report Number(s): CONF-8306122-1; ON: DE83017964
• Resource Relation: Conference: National Institute of Health workshop, Bethesda, MD, USA, 22 Jun 1983
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
BIOCHEMICAL REACTION KINETICS
RECEPTORS
BINDING ENERGY
CHEMICAL BONDS
IN VIVO
LIGANDS
MATHEMATICAL MODELS
NERVE CELLS
POSITRON COMPUTED TOMOGRAPHY
UPTAKE
AMINES
ANIMAL CELLS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ENERGY
HYDROXY COMPOUNDS
KINETICS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
REACTION KINETICS
SOMATIC CELLS
SYMPATHOMIMETICS
TOMOGRAPHY
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