Attomole detection of isotope-labeled compounds in chemical defense research
Conference
·
OSTI ID:567638
AMS detects 14C at zeptomole to femtomole sensitivities. We detected the effect of ChE-blocking pyridostigmine bromide on the CNS uptake of a pyrethroid insecticide at scaled human-equivalent exposures in rats. Significant blood to brain protection from permethrin dosed at 5mg/kg is seen in the CNS of rats receiving pyridostigmine bromide pretreatments in chow at 2mg/kg/day. The synergy of these compounds was suggested as a precursor to some symptoms of `Gulf War Syndrome`.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 567638
- Report Number(s):
- UCRL-JC-125921; CONF-961191-4; ON: DE97053397
- Resource Relation:
- Conference: 1996 Edgewood Research, Development and Engineering Center (RDEC) scientific conference on obscuration and aerosol research, Aberdeen, MD (United States), 19-22 Nov 1996; Other Information: PBD: Nov 1996
- Country of Publication:
- United States
- Language:
- English
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