Nuclear data for production of /sup 117m/Sn for biomedical application
The /sup 117m/Sn(4+)DTPA has been shown to have high uptake in cortical bone with negligible soft-tissue deposition. The long half-life (14 d) of /sup 117m/Sn and its emission of abundant short-range Auger and conversion electrons, make /sup 117m/Sn(4+)DTPA an attractive therapeutic agent for bone tumors. The necessary nuclear data for production of clinical quantities of /sup 117m/Sn using Sb(p,2pxn) reactions at BLIP was obtained. The excitation functions for /sup 121/Sb(p,2p3n) and /sup 123/Sb(p,2p5n) reactions in the regions of 43 less than or equal to E/sub p/ less than or equal to 60 MeV were measured and compared with predicted values obtained from semi-empirical formulae given by Silberberg and Tsao. /sup 117m/Sn is routinely produced at ORNL by thermal neutron activation of /sup 116/Sn. We have investigated the possibility of improving the specific activity of the reactor-produced /sup 117m/Sn by irradiating enriched /sup 116/Sn and /sup 117/Sn in the core of the HFBR. Our results indicate that, due to a strong absorption resonance at E/sub n/ approx. = 110 eV, better specific activity for reactor-produced /sup 117m/Sn can be obtained by irradiating natural tin in the core of a reactor. 7 refs., 1 fig. 1 tab.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); Indiana Univ., Bloomington (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5676300
- Report Number(s):
- BNL-36530; CONF-850507-44; ON: DE85012263
- Resource Relation:
- Conference: International conference on nuclear data for basic and applied science, Santa Fe, NM, USA, 13 May 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TIN 117
RADIOISOTOPE GENERATORS
DTPA
EXPERIMENTAL DATA
ISOMERIC NUCLEI
RADIOPHARMACEUTICALS
RADIOTHERAPY
THERMAL FISSION
AMINO ACIDS
BARYON REACTIONS
CARBOXYLIC ACIDS
CHELATING AGENTS
DATA
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
FISSION
HADRON REACTIONS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NEUTRON REACTIONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
STABLE ISOTOPES
THERAPY
TIN ISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)