Maximum likelihood estimation for cytogenetic dose-response curves

Technical Report · Sat Oct 01 00:00:00 EDT 1983

DOI:https://doi.org/10.2172/5652085· OSTI ID:5652085

Frome, E L; DuFrain, R J

In vitro dose-response curves are used to describe the relation between the yield of dicentric chromosome aberrations and radiation dose for human lymphocytes. The dicentric yields follow the Poisson distribution, and the expected yield depends on both the magnitude and the temporal distribution of the dose for low LET radiation. A general dose-response model that describes this relation has been obtained by Kellerer and Rossi using the theory of dual radiation action. The yield of elementary lesions is kappa(..gamma..d + g(t, tau)d/sup 2/), where t is the time and d is dose. The coefficient of the d/sup 2/ term is determined by the recovery function and the temporal mode of irradiation. Two special cases of practical interest are split-dose and continuous exposure experiments, and the resulting models are intrinsically nonlinear in the parameters. A general purpose maximum likelihood estimation procedure is described and illustrated with numerical examples from both experimental designs. Poisson regression analysis is used for estimation, hypothesis testing, and regression diagnostics. Results are discussed in the context of exposure assessment procedures for both acute and chronic human radiation exposure.

• Research Organization: Union Carbide Corp., Oak Ridge, TN (USA). Nuclear Div.
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5652085
• Report Number(s): ORNL/CSD-123; ON: DE84001582
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
LYMPHOCYTES
GENETIC RADIATION EFFECTS
IN VITRO
LET
LOW DOSE IRRADIATION
MAN
POISSON EQUATION
RADIATION DOSES
RADIOINDUCTION
REGRESSION ANALYSIS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIFFERENTIAL EQUATIONS
DOSES
ENERGY TRANSFER
EQUATIONS
GENETIC EFFECTS
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MATHEMATICS
MUTATIONS
PARTIAL DIFFERENTIAL EQUATIONS
PRIMATES
RADIATION EFFECTS
SOMATIC CELLS
STATISTICS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)