skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Overview of PSB track on gene structure identification in large-scale genomic sequence

Abstract

The recent funding of more than a dozen major genome centers to begin community-wide high-throughput sequencing of the human genome has created a significant new challenge for the computational analysis of DNA sequence and the prediction of gene structure and function. It has been estimated that on average from 1996 to 2003, approximately 2 million bases of newly finished DNA sequence will be produced every day and be made available on the Internet and in central databases. The finished (fully assembled) sequence generated each day will represent approximately 75 new genes (and their respective proteins), and many times this number will be represented in partially completed sequences. The information contained in these is of immeasurable value to medical research, biotechnology, the pharmaceutical industry and researchers in a host of fields ranging from microorganism metabolism, to structural biology, to bioremediation. Sequencing of microorganisms and other model organisms is also ramping up at a very rapid rate. The genomes for yeast and several microorganisms such as H. influenza have recently been fully sequenced, although the significance of many genes remains to be determined.

Authors:
;
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Energy Research, Washington, DC (United States)
OSTI Identifier:
563242
Report Number(s):
ORNL/CP-94807; CONF-980118-
ON: DE98000576; BR: KP1103010; TRN: AHC29803%%79
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Conference
Resource Relation:
Conference: 3. Pacific symposium on biocomputing, Kapalua, HI (United States), 5 Jan 1998; Other Information: PBD: [1998]
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DNA SEQUENCING; MOLECULAR STRUCTURE; MOLECULAR BIOLOGY; DNA; GENES; BIOTECHNOLOGY

Citation Formats

Uberbacher, E C, and Xu, Y. Overview of PSB track on gene structure identification in large-scale genomic sequence. United States: N. p., 1998. Web.
Uberbacher, E C, & Xu, Y. Overview of PSB track on gene structure identification in large-scale genomic sequence. United States.
Uberbacher, E C, and Xu, Y. 1998. "Overview of PSB track on gene structure identification in large-scale genomic sequence". United States. https://www.osti.gov/servlets/purl/563242.
@article{osti_563242,
title = {Overview of PSB track on gene structure identification in large-scale genomic sequence},
author = {Uberbacher, E C and Xu, Y},
abstractNote = {The recent funding of more than a dozen major genome centers to begin community-wide high-throughput sequencing of the human genome has created a significant new challenge for the computational analysis of DNA sequence and the prediction of gene structure and function. It has been estimated that on average from 1996 to 2003, approximately 2 million bases of newly finished DNA sequence will be produced every day and be made available on the Internet and in central databases. The finished (fully assembled) sequence generated each day will represent approximately 75 new genes (and their respective proteins), and many times this number will be represented in partially completed sequences. The information contained in these is of immeasurable value to medical research, biotechnology, the pharmaceutical industry and researchers in a host of fields ranging from microorganism metabolism, to structural biology, to bioremediation. Sequencing of microorganisms and other model organisms is also ramping up at a very rapid rate. The genomes for yeast and several microorganisms such as H. influenza have recently been fully sequenced, although the significance of many genes remains to be determined.},
doi = {},
url = {https://www.osti.gov/biblio/563242}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Dec 31 00:00:00 EST 1998},
month = {Thu Dec 31 00:00:00 EST 1998}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: