Bioluminescence monitor and method for enzymatic determinations. [Patents]
Abstract
An on-line, nonreferenced apparatus for measuring the concentration of a biomarker species in authentic biological samples in solution comprises conduit means for conducting said sample solution from a source of said solution, stream diversion means disposed within the conduit for diverting a predetermined amount of said sample for analysis, means for introducing and independently regulating the flow of one or more reactants disposed in fluid communication with said diverted stream, incubating means within the diverted stream for reacting said reactants and biomarkers to produce a bioluminescence emission, and means disposed within the diverted stream for monitoring said emission intensity which is correlatable to said biomarker concentration.
- Inventors:
- Publication Date:
- OSTI Identifier:
- 5609413
- Application Number:
- ON: DE82007325
- Assignee:
- Dept. of Energy
- DOE Contract Number:
- W-7405-ENG-26
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; 62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL INDICATORS; DIAGNOSTIC USES; MEASURING INSTRUMENTS; BIOLUMINESCENCE; MEASURING METHODS; FLUORESCENCE; ISOENZYMES; PROTEINS; AUTOMATION; EMISSION SPECTROSCOPY; FLUOROSCOPY; LIQUID COLUMN CHROMATOGRAPHY; BIOMEDICAL RADIOGRAPHY; CHROMATOGRAPHY; DIAGNOSTIC TECHNIQUES; LUMINESCENCE; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; RADIOLOGY; SEPARATION PROCESSES; SPECTROSCOPY; USES; 440300* - Miscellaneous Instruments- (-1989); 550600 - Medicine
Citation Formats
Bostick, W. D., Denton, M. S., and Dinsmore, S. R. Bioluminescence monitor and method for enzymatic determinations. [Patents]. United States: N. p., 1981.
Web.
Bostick, W. D., Denton, M. S., & Dinsmore, S. R. Bioluminescence monitor and method for enzymatic determinations. [Patents]. United States.
Bostick, W. D., Denton, M. S., and Dinsmore, S. R. 1981.
"Bioluminescence monitor and method for enzymatic determinations. [Patents]". United States. https://www.osti.gov/servlets/purl/5609413.
@article{osti_5609413,
title = {Bioluminescence monitor and method for enzymatic determinations. [Patents]},
author = {Bostick, W. D. and Denton, M. S. and Dinsmore, S. R.},
abstractNote = {An on-line, nonreferenced apparatus for measuring the concentration of a biomarker species in authentic biological samples in solution comprises conduit means for conducting said sample solution from a source of said solution, stream diversion means disposed within the conduit for diverting a predetermined amount of said sample for analysis, means for introducing and independently regulating the flow of one or more reactants disposed in fluid communication with said diverted stream, incubating means within the diverted stream for reacting said reactants and biomarkers to produce a bioluminescence emission, and means disposed within the diverted stream for monitoring said emission intensity which is correlatable to said biomarker concentration.},
doi = {},
url = {https://www.osti.gov/biblio/5609413},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 28 00:00:00 EDT 1981},
month = {Tue Apr 28 00:00:00 EDT 1981}
}