Solvent-refined-coal (SRC) process: health programs. Research and development report No. 53, Interim report No. 39. Volume III. Pilot plant development work. Part 4: Industrial hygiene, clinical and toxicological programs. Final report of subcontract No. 10, June 1, 1976-June 9, 1978

Technical Report · Sun Nov 01 00:00:00 EST 1981

DOI:https://doi.org/10.2172/5605917· OSTI ID:5605917

This report summarizes the toxicological studies on SRC-I materials completed under Subcontract No. 10 as part of the Health Programs under the Solvent Refined Coal (SRC) Process Contract during the total period of the subcontract, June 1, 1976 through June 9, 1978. The studies were conducted by Industrial Bio-Test Laboratories (IBT) as the subcontractor. A number of acute studies were completed on the products and intermediate streams as well as several subchronic studies. In addition, preliminary dose-ranging, or pilot, studies were completed. None of the materials exhibited high toxicities when administered orally, dermally, or by the inhalation route. Three of the materials proved to be severely or extremely irritating to the eyes. The pilot dermal and teratogenesis studies revealed some evidence of decreased viability in offspring and reduced fetal body weights. The subcontract was terminated for convenience on June 9, 1978 when it became apparent that IBT could not satisfactorily continue the studies.

• Research Organization: Gulf Science and Technology Co., Pittsburgh, PA (USA). Toxicology Dept.; Pittsburg and Midway Coal Mining Co., Englewood, CO (USA)
• DOE Contract Number: AC05-76ET10104
• OSTI ID: 5605917
• Report Number(s): DOE/ET/10104-13; ON: DE82006943
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
01 COAL, LIGNITE, AND PEAT
COAL LIQUIDS
TOXICITY
SOLVENT-REFINED COAL
SRC PROCESS
HEALTH HAZARDS
DOSE-RESPONSE RELATIONSHIPS
EYES
FETUSES
INGESTION
INHALATION
MICE
PROGENY
RABBITS
RATS
RESEARCH PROGRAMS
SKIN
SURVEYS
TERATOGENESIS
WEIGHT
ANIMALS
BODY
BODY AREAS
FACE
FLUIDS
FUELS
HAZARDS
HEAD
INTAKE
LIQUIDS
MAMMALS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
016000 - Coal
Lignite
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010900 - Coal
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