RBE (relative biological effectiveness) of tritium beta radiation to gamma radiation and x-rays analyzed by both molecular and genetic methods
The relative biological effectiveness (RBE) of tritium beta radiation to /sup 60/Co gamma radiation was determined using sex-linked recessive lethals (SLRL) induced in Drosophila melanogaster spermatozoa as the biological effect. The SLRL test, a measure of mutations induced in germ cells transmitted through successive generations, yields a linear dose-response curve in the range used in these experiments. From these ratios of the slopes of the /sup 3/H beta and the /sup 60/ Co gamma radiation linear dose response curves, an RBE of 2.7 is observed. When sources of error are considered, this observation suggests that the tritium beta particle is 2.7 /plus minus/ 0.3 times more effective per unit of energy absorbed in inducing gene mutations transmitted to successive generation than /sup 60/Co gamma radiation. Ion tracks with a high density of ions (high LET) are more efficient than tracks with a low ion density (low LET) in inducing transmissible mutations, suggesting interaction among products of ionization. Molecular analysis of x-ray induced mutations shows that most mutations are deletions ranging from a few base pairs as determined from sequence data to multi locus deletions as determined from complementation tests and Southern blots. 14 refs., 1 fig.
- Research Organization:
- Louisiana State Univ., Baton Rouge, LA (USA). Dept. of Zoology and Physiology
- DOE Contract Number:
- FG05-86ER60393
- OSTI ID:
- 5596676
- Report Number(s):
- CONF-881190-4; ON: DE89015373
- Resource Relation:
- Conference: 3. Japan-US workshop on tritium radiobiology and health physics, Kyoto, Japan, 8-10 Nov 1988; Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GAMMA RADIATION
RADIATION EFFECTS
SPERMATOZOA
MORTALITY
BETA PARTICLES
COBALT 60
DROSOPHILA
IONIZING RADIATIONS
LET
MUTATIONS
RBE
TRITIUM
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHARGED PARTICLES
COBALT ISOTOPES
DIPTERA
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
FLIES
FRUIT FLIES
GAMETES
GERM CELLS
HYDROGEN ISOTOPES
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIATIONS
RADIOISOTOPES
YEARS LIVING RADIOISOT
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals