Selenium and tellurium as carbon substitutes
This review has summarized structure-activity studies with /sup 75/Se- and /sup 123m/Te-labeled radiopharmaceuticals in which the selenium or tellurium heteroatom has been inserted between carbon-carbon bonds. The agents that have been investigated in most detail include steroids for adrenal imaging and long-chain fatty acids, and a variety of other unique agents have also been studied. Because of the great versatility of the organic chemistry of selenium and tellurium, there is continuing interest in the preparation of radiopharmaceuticals labeled with /sup 75/Se, /sup 73/Se, and /sup 123m/Te. There are two important factors which will determine the extent of future interest in such agents. These include the necessity of a decrease in the cost of highly enriched /sup 122/Te to make the reactor production of /sup 123m/Te cost effective. In addition, the potential preparation of large amounts of /sup 73/Se should stimulate the development of /sup 73/Se-labeled radiopharmaceuticals.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5522590
- Report Number(s):
- CONF-800336-1; TRN: 80-007534
- Resource Relation:
- Conference: Radiopharmaceuticals: structure activity relationships symposium, Hartford, CT, USA, 21 Mar 1980
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBOXYLIC ACIDS
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
SELENIUM 77
RADIOCHEMISTRY
STEROIDS
TELLURIUM 123
CARBON
ISOMERIC NUCLEI
SELENIUM 73
TELLURIUM 122
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NONMETALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOACTIVE MATERIALS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SELENIUM ISOTOPES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics