Physiological imaging with PET and SPECT in Dementia

Conference · Sun Oct 01 00:00:00 EDT 1989

OSTI ID:5450667

Jagust, W J ^[1]

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1. California Univ., San Francisco, CA (United States). Dept. of Neurology Lawrence Berkeley Lab., CA (United States)

Dementia is a medical problem of increasingly obvious importance. The most common cause of dementia, Alzheimer's disease (AD) accounts for at least 50% of all cases of dementia, with multi-infarct dementia the next most common cause of the syndrome. While the accuracy of diagnosis of AD may range from 80 to 90%, there is currently no laboratory test to confirm the diagnosis. Functional imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer diagnostic advantages since brain function is unequivocally disturbed in all dementing illnesses. Both PET and SPECT have been utilized in the study of dementia. While both techniques rely on principles of emission tomography to produce three dimensional maps of injected radiotracers, the differences between positron and single photon emission have important consequences for the practical applications of the two procedures. This briefly reviews the technical differences between PET and SPECT, and discusses how both techniques have been used in our laboratory to elucidate the pathophysiology of dementia. 32 refs., 2 figs.

• Research Organization: Lawrence Berkeley Lab., CA (United States)
• Sponsoring Organization: USDOE; DOHHS; USDOE, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 5450667
• Report Number(s): LBL-27935; CONF-8910542-1; ON: DE91017098; CNN: AG07793; AG05890; TRN: 91-024088
• Resource Relation: Conference: Neuroimaging symposium of the world congress of neurology, New Delhi (India), 21-27 Oct 1989
• Country of Publication: United States
• Language: English

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NERVOUS SYSTEM DISEASES
POSITRON COMPUTED TOMOGRAPHY
DIAGNOSTIC USES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
BLOOD FLOW
CARBON 11
CEREBRUM
ELDERLY PEOPLE
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OXYGEN 15
PATHOLOGY
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TECHNETIUM 99
TRACER TECHNIQUES
XENON 133
ADULTS
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
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DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
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IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINORITY GROUPS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN ISOTOPES
POPULATIONS
RADIOISOTOPES
TECHNETIUM ISOTOPES
TOMOGRAPHY
USES
XENON ISOTOPES
YEARS LIVING RADIOI
550601* - Medicine- Unsealed Radionuclides in Diagnostics