The toxicity of inhaled particles of sup 238 PuO sub 2 in dogs

Conference · Tue Jan 01 00:00:00 EST 1991

OSTI ID:5389338

Muggenburg, B A; Guilmette, R A; Griffith, Jr, W C; Hahn, F F; Boecker, B B ^[1]; Gillett, N A ^[2]

---

1. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
2. Genentech, Inc., San Francisco, CA (United States)

This study was conducted to determine the toxicity of inhaled {sup 238}PuO{sub 2} in the dog. Inhalation was selected because it is the mostly likely route of human exposure in the event of an accidental airborne release. Of 166 dog in the study, 72 inhaled 1.5{mu}m and 72 inhaled 3.0 {mu}m activity median aerodynamic diameter particles of {sup 238}PuO{sub 2}. Another 24 dogs inhaled the aerosol vector without plutonium. The aerosol exposures resulted in initial pulmonary burdens ranging from 37 to 0.11 and 55.5 to 0.37 kBq of {sup 238}Pu/kg body mass, of 1.5 {mu}m and 3.0 {mu}, particles, respectively. The particles dissolved slowly resulting in translocation of the Pu to liver, bone and other sites. The dogs were observed for biological effects over their life span. Necropsies were performed at death, and tissues were examined microscopically. The principal late-occurring effects were tumors of the lung, skeleton, and liver. Risk factors estimated for these cancers were 2800 lung cancers/10{sup 4} Gy, 800 liver cancers/10{sup 4} Gy, and 6200 bone cancers/10{sup 4} Gy for dogs. The potential hazard from {sup 238}Pu to humans may include tumors of the lung, bone and liver because of the likelihood of similarity of the dose patterns for the two species. 10 refs., 1 fig., 3 tabs.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5389338
• Report Number(s): CONF-9109241-4; ON: DE91017514
• Resource Relation: Conference: 7. international symposium on inhaled particles, Edinburg (United Kingdom), 16-21 Sep 1991
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAGLES
BIOLOGICAL RADIATION EFFECTS
EXPERIMENTAL NEOPLASMS
RADIOINDUCTION
PLUTONIUM 238
RADIONUCLIDE KINETICS
TOXICITY
RESPIRATORY TRACT CELLS
LOCAL RADIATION EFFECTS
BONE TISSUES
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
INHALATION
LIVER
LUNGS
PARTICLE SIZE
PLUTONIUM OXIDES
RADIATION DOSES
RADIOACTIVE AEROSOLS
RESPIRATORY SYSTEM
SPATIAL DOSE DISTRIBUTIONS
TISSUE DISTRIBUTION
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COLLOIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DOGS
DOSES
EVEN-EVEN NUCLEI
GLANDS
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOISOTOPES
SILICON 32 DECAY RADIOISOTOPES
SIZE
SOLS
SPONTANEOUS FISSION RADIOISOTOPES
TISSUES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOT
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells