Clearance of Tc-99m DTPA aerosol from coal miners' lungs
Alterations in regional epithelial permeability were assessed in 22 retired West Virginia coal miners' lungs by measuring the clearance of inhaled 0.5-..mu..m Tc-99m DTPA aerosol. Activity was measured in both lungs and in regions of interest placed over the lung periphery in the apical, middle, and basal portions of each lung. Clearance rates (T/sub 1/2/) for 5 nonsmokers, 8 ex-smokers, and 9 smokers were significantly faster than for comparable subjects measured elsewhere, who were not coal miners. Regional apex-to-base distributions of DTPA were measured as a function of clearance time and compared with regional ventilation and perfusion. Regional, as well as overall lung clearance curves of 8 smokers and 4 ex-smokers had two components, with overall T/sub 1/2/ of <7 min for the faster one. No correlations were found between T/sub 1/2/ and DLCO or with P(A-a)O/sub 2/. The results of our study suggest that measurement of DTPA clearance is a potentially useful noninvasive technique to assess lung injury in miners exposed to coal dust. 14 refs., 6 figs., 2 tabs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5313846
- Report Number(s):
- BNL-36841; CONF-8509138-2; ON: DE85017514
- Resource Relation:
- Conference: 6. international symposium on inhaled particles, Cambridge, MA, USA, 1 Sep 1985
- Country of Publication:
- United States
- Language:
- English
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01 COAL, LIGNITE, AND PEAT
COAL MINERS
MEDICAL EXAMINATIONS
DTPA
LUNG CLEARANCE
TECHNETIUM 99
EMPHYSEMA
EXPERIMENTAL DATA
INHALATION
ISOMERIC NUCLEI
PARTICLE SIZE
TOBACCO SMOKES
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DATA
DISEASES
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INFORMATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINERS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERSONNEL
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM DISEASES
SIZE
SMOKES
SOLS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
016000 - Coal
Lignite
& Peat- Health & Safety