In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981

Technical Report · Sun Nov 01 00:00:00 EST 1981

DOI:https://doi.org/10.2172/5309681· OSTI ID:5309681

Laurer, G. R.

The design, construction, and testing of a photon detection system which will yield, simultaneously, information proportional to both the magnitude and location of sources of radioactivity are under investigation. The operating principle of the detector system, active collimation, allows spatial resolution by utilizing the crystal elements themselves as the collimating device; hence a greater counting efficiency is attainable. Two approaches have been tested thus far: in the first, the differences in characteristics of various crystals are utilized as the means of separating events occurring in each of five crystals viewed by a single phototube; in the second, smaller, single crystal/phototube elements are used in the array. Mathematical processing of the counts from the individual crystal elements is then employed in conjunction with their geometric relationship to develop both positional data and to quantify the amount of radioactivity. By utilizing crystal elements in an active collimation configuration and incorporating them in an array which permits these crystals to be alternately advanced and retracted in a programmed, ordered manner, a high degree of spatial resolution is achievable without compromising system sensitivity. The experiments include development of the optimal crystal configuration and the evolving of data processing techniques to translate detector response into precise source position information for localization or imaging purposes. Such a system could add another dimension in studies involving uptake, distribution, and retention of radionuclide labeled compounds because of its ability to actively track, in vivo, the distribution of these compounds. In addition, it should be possible to study, dynamically, the motion of organs, such as the heart or lungs, through which these compounds move. (ERB)

• Research Organization: New York Univ., NY (USA). Medical Center
• DOE Contract Number: AS02-78EV04957
• OSTI ID: 5309681
• Report Number(s): DOE/EV/04957-T1; COO-4957-3; ON: DE82005466
• Country of Publication: United States
• Language: English

Related Subjects

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
62 RADIOLOGY AND NUCLEAR MEDICINE
NUCLEAR MEDICINE
GAMMA DETECTION
SOLID SCINTILLATION DETECTORS
DESIGN
FABRICATION
PERFORMANCE TESTING
COLLIMATORS
CRYSTALS
DATA PROCESSING
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
IN VIVO
RADIONUCLIDE KINETICS
SENSITIVITY
SPATIAL RESOLUTION
DATA
DETECTION
INFORMATION
MEASURING INSTRUMENTS
MEDICINE
NUMERICAL DATA
PROCESSING
RADIATION DETECTION
RADIATION DETECTORS
RESOLUTION
SCINTILLATION COUNTERS
TESTING
440101* - Radiation Instrumentation- General Detectors or Monitors & Radiometric Instruments
550601 - Medicine- Unsealed Radionuclides in Diagnostics