Applications of quantitative whole body autoradiographic technique in radiopharmaceutical research
The routine evaluation of radiopharmaceuticals involves dissecting tissue distribution studies (DTDS) and gamma or positron imaging. DTDS have the following disadvantages: since not all tissues can always be sampled, sites of radiopharmaceutical uptake may be missed and because the procedure involves weighing of dissected tissue samples, the spatial resolution of this method is low and determined by the smallest amount that can be weighed accurately. Gamma camera imaging and positron emission tomography though more comprehensive in evaluating the global distribution of a compound, have relative low spatial resolution. Whole body autoradiography of small animals has a much higher spatial resolution as compared to the above and depicts the global distribution of radiopharmaceuticals. A computer-assisted quantification method of WBARG applied to positron, beta, and gamma emitters will complement the method by producing quantitative values comparable to those obtained by dissection and direct tissue counting, with the advantages of depicting the global distribution at high spatial resolution.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States); State Univ. of New York (SUNY), Stony Brook, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5294631
- Report Number(s):
- BNL-30638; CONF-820804-2; ON: DE82010918; TRN: 82-014171
- Resource Relation:
- Conference: 3. world congress of nuclear medicine and biology, Paris, France, 29 Aug 1982
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
MICE
AUTORADIOGRAPHY
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
BIOASSAY
CARBON 14 COMPOUNDS
COBALT 57
COMPARATIVE EVALUATIONS
ECAT SCANNING
FLUORINE 18
GALLIUM 67
GALLIUM 68
INTRAVENOUS INJECTION
IODINE 125
ISOMERIC NUCLEI
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
SPATIAL RESOLUTION
TECHNETIUM 99
TIN 117
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COBALT ISOTOPES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PHOTON EMISSION SCANNING
RADIOISOTOPES
RESOLUTION
RODENTS
STABLE ISOTOPES
TECHNETIUM ISOTOPES
TIN ISOTOPES
TOMOGRAPHY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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