Coupling of dextrans conjugated with boron to gamma globulin: a model for NCT

Conference · Sat Jan 01 00:00:00 EST 1983

OSTI ID:5233832

Elmore, Jr, J J; Borg, D C; Micca, P; Gabel, D

Our project is to meet more effectively the well known primary requirement for treatment with boron-10 neutron capture therapy (NCT): namely, the selective localization of a sufficient amount of boron in or on target cells. Monoclonal antibodies (MCA) to tumor-associated antigens are attractive targeting carriers for boron-10 in terms of the needed selective localization. However the densities of surface receptors on tumor cells have seemed deficient to achieve successful NCT. If one seeks the necessary radiotherapeutic ratios by increasing the numbers of boron atoms or carborane cages bound per MCA, then inactivation of the antibody can occur through loss of receptor specificity and/or by precipitation of the protein. To achieve the goal of overcoming the limitations of antibody binding capacity, we have elected to use water-soluble dextrans as intermediate carriers. This permits each MCA molecule to target many atoms of boron-10 to the specified antigenic receptors while only 5 to 10 of the amino acid residues of the protein are conjugated by dextrans carrying boron-10.

• Research Organization: Brookhaven National Lab., Upton, NY (USA); Bremen Univ. (Germany, F.R.). Dept. of Chemistry
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5233832
• Report Number(s): BNL-34077; CONF-8310253-1; ON: DE84006538
• Resource Relation: Conference: Symposium on neutron capture therapy, Boston, MA, USA, 12 Oct 1983
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BORON 10
EVALUATION
NEUTRON CAPTURE THERAPY
DIAGNOSTIC USES
MONOCLONAL ANTIBODIES
CARBORANES
DEXTRAN
LIQUID COLUMN CHROMATOGRAPHY
ANTIBODIES
BLOOD SUBSTITUTES
BORON COMPOUNDS
BORON ISOTOPES
CARBOHYDRATES
CARBON COMPOUNDS
CHROMATOGRAPHY
DRUGS
HEMATOLOGIC AGENTS
ISOTOPES
LIGHT NUCLEI
MEDICINE
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
POLYSACCHARIDES
RADIOLOGY
RADIOTHERAPY
SACCHARIDES
SEPARATION PROCESSES
STABLE ISOTOPES
THERAPY
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)