Environmental damage in human lymphocytes: Final report, January 1, 1983-September 30, 1986

Technical Report · Wed Jan 01 00:00:00 EST 1986

DOI:https://doi.org/10.2172/5200148· OSTI ID:5200148

Norman, A.

Our overall objectives have been to develop better assays for chromosome damage in human populations and to use these assays in order to gain a deeper understanding of the sources of that damage. Our primary emphasis recently has been on the micronucleus (MN) assay in peripheral blood lymphocytes because it provides a relatively simple, rapid and reliable measure of chromosome damage. Perhaps our most important accomplishments have been to demonstrate that fact, to improve the assay by controlling for cell division, to demonstrate the feasibility of automating the assay, and to apply it to an investigation of theeffects of low level radiation exposure.

• Research Organization: Univ. of California, Los Angeles, CA (United States)
• DOE Contract Number: AS03-76EV70118
• OSTI ID: 5200148
• Report Number(s): DOE/EV/70118-T2; ON: DE88007579
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
BIOASSAY
RADIOINDUCTION
DNA
ULTRASTRUCTURAL CHANGES
IONIZING RADIATIONS
DOSE-RESPONSE RELATIONSHIPS
CELL PROLIFERATION
DNA REPAIR
GAMMA RADIATION
HUMAN POPULATIONS
LYMPHOCYTES
MAN
MITOSIS
PROGRESS REPORT
RESPONSE MODIFYING FACTORS
TIME DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIVISION
CONNECTIVE TISSUE CELLS
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MORPHOLOGICAL CHANGES
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PRIMATES
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture