Determination of the lumped constant and the kinetic constants for deoxyglucose and fluorodeoxyglucose in man
If both the time course of the arterial plasma radionuclide concentration and the brain tissue radionuclide concentrations are known, it is possible to calculate the kinetic constants (k/sub 1/*, k/sub 2/*, k/sub 3/*, k/sub 4/*) of the glucose analogue. In a series of male subjects, arterial blood samples were obtained at frequent intervals immediately following the bolus administration of /sup 18/F-FDG and then at less frequent intervals for up to 5 hours after the radionuclide administration. The tissue time course was obtained by making positron emission tomographic scans every three minutes for 30 minutes and then at less frequent intervals for 5 hours. These images were used to construct the time course of /sup 18/F activity in gray and white matter structures. Using these values for the lumped constants and the kinetic constants, the values obtained for the global metabolic rate for glucose in two series of young male subjects were 4.99 +- 0.23 and 5.55 +- 0.37 mg/100 g/min when /sup 11/C-DG and /sup 18/F-FDG were used as tracers respectively.
- Research Organization:
- Pennsylvania Univ., Philadelphia (USA). Cerebrovascular Research Center; Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5179330
- Report Number(s):
- BNL-36937; CONF-8506187-2; ON: DE86000317
- Resource Relation:
- Conference: 12. international symposium on cerebral blood flow and metabolism, Lund, Sweden, 16 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BRAIN
POSITRON COMPUTED TOMOGRAPHY
FLUORODEOXYGLUCOSE
BIOCHEMICAL REACTION KINETICS
FLUORINE 18
GLUCOSE
MAN
METABOLISM
RADIOPHARMACEUTICALS
ALDEHYDES
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
REACTION KINETICS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics