In-vitro and in-vivo characterization of ruthenium-bleomycin compared to cobalt- and copper-bleomycin
Bleomycin (BLM) has undergone extensive investigation both as a cancer chemotherapeutic agent, and as a carrier for radionuclides for tumor imaging. The available methods or the radionuclides used, however, have had limited effectiveness. Although labeling of BLM with /sup 103/Ru has been reported earlier, we carried out a study to develop a more reproducible method of labeling particularly for use with Brookhaven Linac Isotope Producer produced /sup 97/Ru. Ruthenium-97 has favorable physical properties that make it ideal for imaging applications: decay by electron capture; ..gamma.. 216 keV, 85%; t/sub 1/2/ 2.9 d. A novel method based on the reduction of Ru/sup 3 +/ to Ru/sup 2 +/ using stannous chloride was investigated for labeling BLM with /sup 97/Ru and/or /sup 103/Ru. In-vitro and in vivo comparisons of the product(s) with /sup 57/Co and /sup 67/Cu-labeled BLM were also carried out. 4 refs., 3 tabs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA). Medical Dept.
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5178862
- Report Number(s):
- BNL-38422; CONF-860627-2; ON: DE87000002
- Resource Relation:
- Conference: 33. annual meeting of the Society of Nuclear Medicine, Washington, DC, USA, 22 Jun 1986
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cytotoxic activity, tumor accumulation, and tissue distribution of ruthenium-103-labeled bleomycin
Ruthenium-97 labeled compounds: a new class of radiopharmaceuticals. [Preparation, tissue distribution, and imaging studies]
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BLEOMYCIN
LABELLING
BLOOD
COBALT 57
COPPER 67
EXPERIMENTAL NEOPLASMS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUNGS
MUSCLES
RADIOPHARMACEUTICALS
RUTHENIUM 103
RUTHENIUM 97
THIN-LAYER CHROMATOGRAPHY
TISSUE DISTRIBUTION
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHROMATOGRAPHY
COBALT ISOTOPES
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RUTHENIUM ISOTOPES
SEPARATION PROCESSES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400700 - Radiochemistry & Nuclear Chemistry