Relevance of phenotypic variation in risk assessment: The scientific viewpoint
A number of examples are presented indicating the types of variation that may be expected in the responses of the human population to deleterious agents of an endogeneous or exogenous nature. If one assumes that the variations in repair in the normal population are reflected in large variations in carcinogenic risk per unit of exposure, then the dose-response curves at low doses cannot be extrapolated from high doeses without knowing the distribution of sensitivities among humans. The probability of determining this range by ecpidemiological studies on a random population by small. On the other hand, the probability of determining the range by careful genetic and molecular studies appears high enough so that such experiments now are being carried out. They cannot be carried out on real populations, using chronic exposures. Hence, the ability to estimate dose-response relations in the low dose region on human populations can only be by making theoretical constructs that, in turn, are dependent on fundamental research. 12 refs., 2 tabs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5168316
- Report Number(s):
- BNL-40909; CONF-861238-1; ON: DE88007051
- Resource Relation:
- Conference: Phenotypic variation in populations: relevance to risk assessment, Upton, NY, USA, 7 Dec 1986
- Country of Publication:
- United States
- Language:
- English
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DNA REPAIR
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RESPONSE MODIFYING FACTORS
SKIN
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ULTRAVIOLET RADIATION
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