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Title: A comparison of continuous pneumatic nebulization and flow injection-direction injection nebulization for sample introduction in inductively coupled plasma-mass spectrometry

Abstract

Samples containing Ni, Cd, Pb, and U were analyzed eighteen times over a two-month period using inductively coupled plasma-mass spectrometry (ICP-MS). Sample introduction was accomplished by either flow injection-direct injection nebulization (FI-DIN) or continuous pneumatic nebulization (CPN). Using comparable instrumental measurement procedures, FI-DIN analyses were 33% faster and generated 52% less waste than CPN analyses. Instrumental limits of detection obtained with FI-DIN and CPN were comparable but not equivalent (except in the case of Pb) because of nebulizer-related differences in sensitivity (i.e., signal per unit analyte concentration) and background. Substantial and statistically significant differences were found between FI-DIN and CPN Ni determinations, and in the case of laboratory waste samples, there were also small but statistically significant differences between Cd determinations. These small (2 to 3%) differences were not related to polyatomic ion interference (e.g., {sup 95}Mo{sup 16}O{sup +}), but in light of the time and waste savings to be realized, they should not preclude the use of FI-DIN in place of CPN for determination of Cd, Pb, U, and similar elements present at trace concentrations.

Authors:
;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Energy Research, Washington, DC (United States)
OSTI Identifier:
510295
Report Number(s):
ANL/CMT/PP-87817
ON: DE97008110; TRN: AHC29717%%7
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1997]
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; ICP MASS SPECTROSCOPY; SAMPLE HOLDERS; SAMPLE PREPARATION; COMPARATIVE EVALUATIONS; NICKEL; CADMIUM; LEAD; URANIUM; TRACE AMOUNTS; ATOMIZATION; ACCURACY

Citation Formats

Crain, J S, and Kiely, J T. A comparison of continuous pneumatic nebulization and flow injection-direction injection nebulization for sample introduction in inductively coupled plasma-mass spectrometry. United States: N. p., 1997. Web. doi:10.2172/510295.
Crain, J S, & Kiely, J T. A comparison of continuous pneumatic nebulization and flow injection-direction injection nebulization for sample introduction in inductively coupled plasma-mass spectrometry. United States. https://doi.org/10.2172/510295
Crain, J S, and Kiely, J T. 1997. "A comparison of continuous pneumatic nebulization and flow injection-direction injection nebulization for sample introduction in inductively coupled plasma-mass spectrometry". United States. https://doi.org/10.2172/510295. https://www.osti.gov/servlets/purl/510295.
@article{osti_510295,
title = {A comparison of continuous pneumatic nebulization and flow injection-direction injection nebulization for sample introduction in inductively coupled plasma-mass spectrometry},
author = {Crain, J S and Kiely, J T},
abstractNote = {Samples containing Ni, Cd, Pb, and U were analyzed eighteen times over a two-month period using inductively coupled plasma-mass spectrometry (ICP-MS). Sample introduction was accomplished by either flow injection-direct injection nebulization (FI-DIN) or continuous pneumatic nebulization (CPN). Using comparable instrumental measurement procedures, FI-DIN analyses were 33% faster and generated 52% less waste than CPN analyses. Instrumental limits of detection obtained with FI-DIN and CPN were comparable but not equivalent (except in the case of Pb) because of nebulizer-related differences in sensitivity (i.e., signal per unit analyte concentration) and background. Substantial and statistically significant differences were found between FI-DIN and CPN Ni determinations, and in the case of laboratory waste samples, there were also small but statistically significant differences between Cd determinations. These small (2 to 3%) differences were not related to polyatomic ion interference (e.g., {sup 95}Mo{sup 16}O{sup +}), but in light of the time and waste savings to be realized, they should not preclude the use of FI-DIN in place of CPN for determination of Cd, Pb, U, and similar elements present at trace concentrations.},
doi = {10.2172/510295},
url = {https://www.osti.gov/biblio/510295}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 1997},
month = {Fri Aug 01 00:00:00 EDT 1997}
}