Physical measurements of Cu{sup 2+}-complexes of bilirubin
- Argonne National Lab., IL (United States)
- Peking Univ., Beijing (China). Chemistry Dept.
- Univ. of Texas Medical Branch, Galveston, TX (United States). Div. of Gastroenterology
Copper is known to form complexes with bilirubin (H{sub 2}BR). Such complexes have received increased attention due to their clinical significance as free-radical scavengers. The purpose of this study was to examine a series of Cu{sup 2+}BR complexes to ascertain the nature of the binding between Cu{sup 2+} and BR. Several physical measurements of the salts were made, such as Fourier Transform Infrared (FT-IR), Fourier Transform Raman spectroscopy (FT-R), and Electron Paramagnetic Resonance (EPR). The complexes were prepared by dissolving protonated BR in NaOH, and adding different ratios of aqueous CuCl{sub 2}. At ratios of Cu{sup 2+}:H{sub 2}BR of 1:1 and 2:1, soluble complexes were formed. In solution EPR spectra demonstrated 9 hyperfine peaks, which from the splitting, is indicative of Cu{sup 2+} coordinated to 4 nitrogen atoms coming from 2 molecules of BR.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 505332
- Report Number(s):
- ANL/CHM/PP-88133; CONF-9504291-1; ON: DE97007861; TRN: AHC29716%%84
- Resource Relation:
- Conference: International Bilirubin workshop, Trieste (Italy), 6-8 Apr 1995; Other Information: PBD: [1995]
- Country of Publication:
- United States
- Language:
- English
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